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ALS-8112 - 10mM in DMSO , CAS No.1445379-92-9
AVAILABLE TO ORDER
GRADE & PURITY 10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Why this grade
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
ALS-8112 is a potent and selective respiratory syncytial virus ( RSV ) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC 50 of 0.02 μM.
In Vitro
The 5'-triphosphate form of ALS-8112 (ALS-8112-TP) is the active form of the drug and selectively inhibits RSV polymerase through chain termination of RNA synthesis. ALS-008112 enters various types of epithelial cells in the respiratory tract and is subsequently phosphorylated to form an intracellular nucleoside triphosphate with a half-life of approximately 29 hours. The nucleoside triphosphate analogue inhibits RSV replication by means of chain termination. ALS-8112 is a pan-strain inhibitor of RSV replication in vitro . The RNA transcription activity of the RSV–RNP complex is dose-proportionally inhibited by ALS-8112-TP with an IC 50 of 0.020 ± 0.008 μM . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:IC50: 0.02 μM ( RSV )
Specifications
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
ALS-8112 is a potent and selective respiratory syncytial virus ( RSV ) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC 50 of 0.02 μM.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Names and Identifiers
| Isomeric SMILES | C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@](O2)(CO)CCl)O)F |
|---|---|
| Alternate CAS | 1445379-92-9 |
| PubChem CID | 71621663 |
| Molecular Weight | 293.68 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Citations of This Product
References
| 1. Jian Chen, Dongya Zhang, Yan Zou, Zhongjie Wang, Mingcong Hao, Meng Zheng, Xue Xue, Xiaoxi Pan, Yiqing Lu, Jiefei Wang, Bingyang Shi. (2018) Developing a pH-sensitive Al(OH)3 layer-mediated UCNP@Al(OH)3/Au nanohybrid for photothermal therapy and fluorescence imaging in vivo. Journal of Materials Chemistry B, 6 (47): (7862-7870). [PMID:32255031] [10.1039/C8TB02213E] |
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