AMG7703 - 10mM in DMSO , CAS No.1103523-24-5

CAS: 1103523-24-5 Cat. No.: A656624 Summenformel: C₁₄H₁₅ClN₂OS Molekulargewicht: 294.80

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

AMG7703 is a selective and allosteric agonists of FFA2 ( GPR43 ), the receptor for short-chain fatty acids (SCFAs), acetate, and propionate. AMG7703 can be used to research for in inflammatory and metabolic.

In Vitro

AMG7703 (phenylacetamide 1) (30 μM) shows selectivity on FFA2 (GPR43) over FFA1 (GPR40) and FFA3 (GPR41) with in Chinese hamster ovary cells. AMG7703 (0.041, 0.123, 0.37, 1.11 μM) acts as an FFA2 allosteric agonist, activates Gα i coupled signaling pathway. AMG7703 (1, 3, 10, 30 μM) results in Gα i -dependent inhibition of lipolysis in adipocytes (3T3L1). AMG7703 (0.041, 0.123, 0.37, 1.11 μM) exhibits allosteric activity and inhibits Gα i -coupled cAMP with IC 50 values of 0.7 μM (hFFA2) and 0.96 μM (mFFA2), respectively; as for Gα q -coupled aequorin inhibition, with EC 50 s of 0.45 μM (hFFA2) and 1.27 μM (mFFA2), respectively. AMG7703 (0-1 μM) shows the positive cooperating effect of acetate and stimulates calcium mobilization in a concentration-dependent manner in CHO cell stably expressing hFFA2 and aequorin. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

AMG7703 is a selective and allosteric agonists of FFA2 ( GPR43 ), the receptor for short-chain fatty acids (SCFAs), acetate, and propionate. AMG7703 can be used to research for in inflammatory and metabolic.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

AGONIST

Namen und Kennungen

• Molekulargewicht: 294.80

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1103523-24-5, the molecular formula is C14H15ClN2OS, and the molecular weight is 294.80 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.