Amiloride - Moligand™, 10 mM in DMSO , CAS No.2609-46-3

CAS: 2609-46-3 Cat. No.: A1499343 Molecular Weight: 229.63 Beilstein Registry Number: 616612 EC Number: 220-024-7 PubChem CID: 16231

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Amiloride (MK-870) is an inhibitor of both epithelial sodium channel ( ENaC) and urokinase-type plasminogen activator receptor ( uTPA). Amiloride is a blocker of polycystin-2 (PC2; TRPP2) channel.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Product Properties

• pKa: pKa: 7.81 (Predicted), pKa: 3.78 (Predicted)
• Ki Data: uPA: Ki= 2.51 μM (human); Adenosine A2A-R: Ki= 3.28 μM (human); Solute carrier family 22 member 2: Ki= 4.7 μM (rat); Solute carrier family 22 member 1: Ki= 6.9 μM (rat); Amine oxidase, copper containing: Ki= 10 μM (rat)

Names and Identifiers

• Isomeric SMILES: C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
• PubChem CID: 16231
• Molecular Weight: 229.63
• Beilstein: 616612

Chemical and Physical Properties

• Refractive Index: n20D1.89 (Predicted)
• Boil Point(°C): ~557.9° C at 760 mmHg (Predicted)
• Melt Point(°C): 185.21° C (Predicted)

References

1. Ruoning Wang, Qifan Liang, Xinru Zhang, Zhenning Di, Xiaohong Wang, Liuqing Di.  (2022)  Tumor-derived exosomes reversing TMZ resistance by synergistic drug delivery for glioma-targeting treatment.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:35487070] [10.1016/j.colsurfb.2022.112505]