Aminophylline - 10mM in DMSO , Adenosine receptor antagonist, CAS No.317-34-0, Adenosine receptor antagonist

CAS: 317-34-0 Cat. No.: A408079 Summenformel: C₁₆H₂₄N₁₀O₄ Molekulargewicht: 420.43 EG-Nummer: 206-264-5

GRADE & PURITY 10mM in DMSO

Synonyms

Phyllocontin | 3,​9-​dihydro-​1,​3-​dimethyl-1H-​purine-​2,​6-​dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Aminophylline Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.
In vitro

In vivo

Cell Data

cell lines：UMSCC10B, UMSCC14B, UMSCC17B, UMSCC22B, and UMSCC35, UMSCC38 cell lines

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyme

Phyllocontin | 3,​9-​dihydro-​1,​3-​dimethyl-1H-​purine-​2,​6-​dione

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Adenosine receptor antagonist

Namen und Kennungen

• Isomere SMILES: CN1C2=C(C(=O)N(C1=O)C)NC=N2.CN1C2=C(C(=O)N(C1=O)C)NC=N2.C(CN)N
• WGK Deutschland: 3
• RTECS: XH5600000
• UN-Nummer: 2811
• Molekulargewicht: 420.43
• Reaxy-Rn: 5784418
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5784418&ln=

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 100 mg/mL Water: Insoluble; Ethanol: 100 mg/mL
• Schmelzpunkt (°C): 269-270°C

Referenzen

1. Chaozhi Ma, Liyuan Zou, Yu Xia, Yijun Tu, Daquan Xue, Yanfang Yang, Dan Liu, Yanwen Liu, Hezhen Wu, Hanxiong Dan, Pengtao You.  (2018)  Extracts of Coleus forskohlii relieves cough and asthma symptoms via modulating inflammation and the extracellular matrix.  JOURNAL OF CELLULAR BIOCHEMISTRY,  120  (6): (9648-9655).  [PMID:30520122] [10.1002/jcb.28243]

2. Xingxing Duan, Bufan Yu, Guangrong Jin, Dengliang Zhang, Jiangshan Chen, Dongge Ma.  (2024)  Modification of mixed-halide quasi-2D perovskites by aminophylline towards efficient and spectrally stable blue light-emitting diodes with low efficiency roll-off.  Journal of Materials Chemistry C,      [PMID:] [10.1039/D4TC04214J]