Aminophylline - 10mM in DMSO , Adenosine receptor antagonist, CAS No.317-34-0, Adenosine receptor antagonist

CAS: 317-34-0 Cat. No.: A408079 Molecular Weight: 420.43 EC Number: 206-264-5

GRADE & PURITY 10mM in DMSO

Synonyms

Phyllocontin | 3,​9-​dihydro-​1,​3-​dimethyl-1H-​purine-​2,​6-​dione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Aminophylline Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.
In vitro

In vivo

Cell Data

cell lines：UMSCC10B, UMSCC14B, UMSCC17B, UMSCC22B, and UMSCC35, UMSCC38 cell lines

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Phyllocontin | 3, ​9-​dihydro-​1, ​3-​dimethyl-1H-​purine-​2, ​6-​dione

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Adenosine receptor antagonist

Names and Identifiers

• Isomeric SMILES: CN1C2=C(C(=O)N(C1=O)C)NC=N2.CN1C2=C(C(=O)N(C1=O)C)NC=N2.C(CN)N
• WGK Germany: 3
• RTECS: XH5600000
• UN Number: 2811
• Molecular Weight: 420.43
• Reaxy-Rn: 5784418
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5784418&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 100 mg/mL Water: Insoluble; Ethanol: 100 mg/mL
• Melt Point(°C): 269-270°C

References

1. Chaozhi Ma, Liyuan Zou, Yu Xia, Yijun Tu, Daquan Xue, Yanfang Yang, Dan Liu, Yanwen Liu, Hezhen Wu, Hanxiong Dan, Pengtao You.  (2018)  Extracts of Coleus forskohlii relieves cough and asthma symptoms via modulating inflammation and the extracellular matrix.  JOURNAL OF CELLULAR BIOCHEMISTRY,  120  (6): (9648-9655).  [PMID:30520122] [10.1002/jcb.28243]

2. Xingxing Duan, Bufan Yu, Guangrong Jin, Dengliang Zhang, Jiangshan Chen, Dongge Ma.  (2024)  Modification of mixed-halide quasi-2D perovskites by aminophylline towards efficient and spectrally stable blue light-emitting diodes with low efficiency roll-off.  Journal of Materials Chemistry C,      [PMID:] [10.1039/D4TC04214J]