Andrographolide - Moligand™, 10mM in DMSO , Agonist of TAS2R46;Agonist of TAS2R50;Agonist of TAS2R8, CAS No.5508-58-7, Agonist of TAS2R46;Agonist of TAS2R50;Agonist of TAS2R8

CAS: 5508-58-7 Cat. No.: A407762 Molecular Weight: 350.45 Beilstein Registry Number: 42762 EC Number: 226-852-5

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

2(3H)-Furanone, 3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, (3E,4S)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Andrographolide Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

2(3H)-Furanone, 3-[2-[(1R, 4aS, 5R, 6R, 8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5, 8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, (3E, 4S)-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of TAS2R46;Agonist of TAS2R50;Agonist of TAS2R8

Names and Identifiers

• Isomeric SMILES: C[C@@]12CC[C@H]([C@@]([C@H]1CCC(=C)[C@H]2C/C=C/3\[C@@H](COC3=O)O)(C)CO)O
• WGK Germany: 3
• RTECS: LU3490750
• Alternate CAS: 5508-58-7
• MeSH Entry Terms: 17-hydro-9-dehydro-andrographolide;andrographolide;isoandrographolide
• Molecular Weight: 350.45
• Beilstein: 42762
• Reaxy-Rn: 29234534
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29234534&ln=

Associated Targets(Human)

TAS2R8 Tchem Taste receptor type 2 member 8 (0 Activities)

Discover Target: TAS2R8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TAS2R46 Tchem Taste receptor type 2 member 46 (0 Activities)

Discover Target: TAS2R46

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TAS2R50 Tchem Taste receptor type 2 member 50 (0 Activities)

Discover Target: TAS2R50

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Specific Rotation[α]: -126° (C=1.5,AcOH)
• Melt Point(°C): 229-232°C

References

1. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang.  (2021)  Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:34224966] [10.1016/j.jchromb.2021.122767]

2. Song-Xue Yang, Wei-Lie Xiao, Xing-Jie Zhang.  (2025)  Essential oil of Saposhnikovia divaricata mitigates Cutibacterium acnes-induced inflammatory acne via Nrf2 pathway activation and NF-κB pathway inhibition.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:41015324] [10.1016/j.jep.2025.120647]

3. Wenshu Zou, Kai Zhang, Zhengying Qiu, Ruihua Xin, Guibo Wang, Jingyan Zhang, Jianxi Li.  (2022)  Asiatic acid and andrographolide reduce hippocampal injury through suppressing neuroinflammation caused by Salmonella typhimurium infection.  FOOD AND CHEMICAL TOXICOLOGY,      [PMID:36581090] [10.1016/j.fct.2022.113584]

4. Zhaohong Wang, Hui Chen, Xufan Cai, Heqi Bu, Shengzhang Lin.  (2024)  Andrographolide induces protective autophagy and targeting DJ-1 triggers reactive oxygen species-induced cell death in pancreatic cancer.  PeerJ,      [PMID:38952980] [10.7717/peerj.17619]