Angstrom6 - ≥98% , CAS No.220334-14-5

CAS: 220334-14-5 Cat. No.: A650893 Summenformel: C₃₉H₆₂N₁₀O₁₅ Molekulargewicht: 910.97

QUALITÄT & REINHEIT ≥98%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling.

In Vitro

Angstrom6 is effective at blocking the migration of the OVCAR8, OVCAR3, ES2, IGROV-1, MDA-MB-468, and MDA-MB361 cells with IC 50 s in the range of 10 to 100 nM. ?\nAngstrom6 potentiates the CD44-dependent adhesion of cancer cells to hyaluronic acid and activated CD44-mediated signaling, as evidenced by focal adhesion kinase and MAP/ERK kinase phosphorylation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Angstrom6 (100 mg/kg; s.c. twice daily) reduces the number of lung foci generated by the i.v. injection of B16-F10 melanoma cells by 50%. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57Bl/6 mice (bearing B16-F10 cells)Dosage: 100 mg/kg Administration: S.c.; twice a day for 11 days Result: Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control.

Form:Solid

Spezifikationen

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration

Storage

Desiccated,Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥98%

Namen und Kennungen

Molekulargewicht

910.97

Chemische und physikalische Eigenschaften

• Löslichkeit: H2O : ≥ 100 mg/mL (109.77 mM) DMSO : 100 mg/mL (109.77 mM; Need ultrasonic)