10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Übersicht
Anticancer agent 73 (compound CIB-3b) is a anticancer agent, potently targeting TAR RNA-binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 suppresses the proliferation and metastasis of HCC in vitro and in vivo.
In Vitro
Anticancer agent 73 (compound CIB-3b) (10 μM; 6 hours) increases the expression of E-cadherin and decreases the protein expression levels of fibronectin, N-cadherin, and vimentin in SK-HEP-1 cells; inhibits the proliferation and migration of SK-HEP-1, HCCLM3 and MHCC97L cells by inhibiting miRNA biogenesis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Anticancer agent 73 (10, 25 and 50 mg/kg; IV, every 2 days for 4 weeks) attenuates the proliferation and migration of SK-HEP-1 and SK-HEP-1 implanted in SCID mice MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Specifications
Spezifikationen & Reinheit
10mM in DMSO
Biochemische und physiologische Mechanismen
Anticancer agent 73 (compound CIB-3b) is a anticancer agent, potently targeting TAR RNA-binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. An
Storage
Store at -80°C
Verschickt in
Dry ice packs + Cold packs
Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.
Aktionsart
INHIBITOR
Namen und Kennungen
Molekulargewicht
261.27
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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