AP C5 - ≥98%(HPLC) , CAS No.2234272-10-5

CAS: 2234272-10-5 Cat. No.: A288897 Molecular Weight: 275.31

GRADE & PURITY ≥98%(HPLC)

Synonyms

4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Explanation：

AP C5 is a potent and selective protein kinase G type II (PKG2) inhibitor (pIC50 = 7.2). Displays >20-fold selectivity for PKG2 over PKG1 and PKA (pIC50 values are 4.6 and 4.8 for PKG1 and PKA, respectively). Blocks 8-pCPT-cGMP-dependent VASP phosphorylation in intestinal organoids. Also attenuates toxin-stimulated anion secretory responses in mouse intestinal tissue.

Specifications

Synonyms

4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine

Specifications & Purity

≥98%(HPLC)

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%(HPLC)

Names and Identifiers

• Canonical Smiles: C#CCNC1=NC=CC(=N1)C2=CC=C(C=C2)N3C=CN=C3
• IUPAC Name: 4-(4-imidazol-1-ylphenyl)-N-prop-2-ynylpyrimidin-2-amine
• InChIKey: QKHQFSQJQKGFAA-UHFFFAOYSA-N
• INCHI: 1S/C16H13N5/c1-2-8-18-16-19-9-7-15(20-16)13-3-5-14(6-4-13)21-11-10-17-12-21/h1,3-7,9-12H,8H2,(H,18,19,20)
• Molecular Weight: 275.31
• Reaxy-Rn: 32869944
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32869944&ln=

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 27.53, Max Conc. mM: 100; Solvent:1eq. HCl, Max Conc. mg/mL: 27.53, Max Conc. mM: 100