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In 0 peer-reviewten Publikationen zu Chromatographie, organischer Synthese und Kreuzkupplungsreaktionen zitiert.
AR453588 is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC 50 of 42 nM. AR453588 shows anti-hyperglycemic activity.
In Vivo
AR453588 (3-30 mg/kg; p.o) lowers post-prandial glucose in normal C57BL/6J mice . AR453588 (3-30 mg/kg; p.o.; once-daily for 14 days) shows anti-hyperglycemic activity in a dose-ranging 14 day ob/ob mouse . AR453588 (10 mg/kg; p.o.) treatment shows that the T max , AUC inf , Vss, C max and F are 1.0 mL/min/kg, 4.65 h μg /mL, 1.67 μg /mL and 60.3%, respectively . AR453588 (1 mg/kg; i.v.) treatment shows that the CL, AUC inf , Vss, and t 1/2 are 21.6 mL/min/kg, 0.77 h μg /mL, 0.746 L/kg and 1.28 hours, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male diabetic ob/ob mice Dosage: 3, 10, 30 mg/kg Administration: Orally once-daily for 14 days Result: Lowered the fasted blood glucose from the control animals on day 14 as well as the AUC of the OGTT (oral glucose tolerance tests). Animal Model: Male CD-1 mice Dosage: 10 mg/kg Administration: p.o. (Pharmacokinetic Analysis) Result: The T max , AUC inf , Vss, C max and F were 1.0 mL/min/kg, 4.65 h μg /mL, 1.67 μg /mL and 60.3%, respectively.
Form:Solid
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Spezifikationsblatt ansehen →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic oxygen compounds |
| Klasse | Organooxygen compounds |
| Subclass | Ethers |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Diarylethers |
| Alternative Parents | Diarylthioethers N-acylpiperidines Aminopyridines and derivatives Methylpyridines Imidolactams Thiadiazoles Tertiary carboxylic acid amides Acetamides Heteroaromatic compounds Tertiary amines Amino acids and derivatives Sulfenyl compounds Secondary amines Azacyclic compounds Organic oxides Carbonyl compounds Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Diarylthioether - Diaryl ether - N-acyl-piperidine - Aryl thioether - Aminopyridine - Methylpyridine - Pyridine - Piperidine - Imidolactam - Tertiary carboxylic acid amide - Azole - Thiadiazole - Heteroaromatic compound - Acetamide - Amino acid or derivatives - Tertiary amine - Carboxamide group - Azacycle - Carboxylic acid derivative - Organoheterocyclic compound - Sulfenyl compound - Thioether - Secondary amine - Organic nitrogen compound - Amine - Organic oxide - Organonitrogen compound - Organosulfur compound - Hydrocarbon derivative - Carbonyl group - Aromatic heteromonocyclic compound |
| Beschreibung | This compound belongs to the class of organic compounds known as diarylethers. These are organic compounds containing the dialkyl ether functional group, with the formula ROR', where R and R' are aryl groups. |
| External Descriptors | Not available |
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| Löslichkeit | DMSO : 100 mg/mL (192.44 mM; Need ultrasonic) |
|---|---|
| Molekulargewicht | 519.600 g/mol |
| XLogP3 | 4.200 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 7 |
| Exact Mass | 519.151 Da |
| Monoisotopic Mass | 519.151 Da |
| Topological Polar Surface Area | 160.000 Ų |
| Heavy Atom Count | 36 |
| Formal Charge | 0 |
| Complexity | 714.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
