AS 1269574 - Moligand™, ≥98%(HPLC) , Agonist of GPR119, CAS No.330981-72-1, Agonist of GPR119

CAS: 330981-72-1 Cat. No.: A288879 Summenformel: C₁₃H₁₄BrN₃O Molekulargewicht: 308.17

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

HY-107535 | 2-(2-(4-bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol | DTXSID90416373 | 2-[[2-(4-Bromophenyl)-6-methyl-4-pyrinidinyl]amino]ethanol | 2-[[2-(4-bromophenyl)-6-methylpyrimidin-4-yl]amino]ethanol | AKOS005229115 | Z1095349900 | Q27074518 | 2-(

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyme

HY-107535 | 2-(2-(4-bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol | DTXSID90416373 | 2-[[2-(4-Bromophenyl)-6-methyl-4-pyrinidinyl]amino]ethanol | 2-[[2-(4-bromophenyl)-6-methylpyrimidin-4-yl]amino]ethanol | AKOS005229115 | Z1095349900 | Q27074518 | 2-(

Spezifikationen & Reinheit

Moligand™, ≥98%(HPLC)

Biochemische und physiologische Mechanismen

GPR119 receptor agonist (EC50= 2.5μM in HEK293 cells expressing human GPR119). Enhances insulin secretion stimulated by glucosein vivo. Stimulates proGlukagon gene promoter actvity. Orally available.

Storage

Protected from light,Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

AGONIST

Mechanismus der Wirkung

Agonist of GPR119

Reinheit

≥98%(HPLC)

Namen und Kennungen

• Pubchem Sid: 528763137
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/528763137
• Kanonisches Lächeln: CC1=CC(=NC(=N1)C2=CC=C(C=C2)Br)NCCO
• IUPAC Name: 2-[[2-(4-bromophenyl)-6-methylpyrimidin-4-yl]amino]ethanol
• InChIKey: DUKPGOOUJNUIOI-UHFFFAOYSA-N
• INCHI: 1S/C13H14BrN3O/c1-9-8-12(15-6-7-18)17-13(16-9)10-2-4-11(14)5-3-10/h2-5,8,18H,6-7H2,1H3,(H,15,16,17)
• Isomere SMILES: CC1=CC(=NC(=N1)C2=CC=C(C=C2)Br)NCCO
• Molekulargewicht: 308.17
• Reaxy-Rn: 22432810
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22432810&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Diazines
      • Subclass Pyrimidines and pyrimidine derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Diazines
• Subclass: Pyrimidines and pyrimidine derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Aminopyrimidines and derivatives
• Alternative Parents: Bromobenzenes Imidolactams Aryl bromides Heteroaromatic compounds Azacyclic compounds Alkanolamines Primary alcohols Organopnictogen compounds Organobromides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Aminopyrimidine - Bromobenzene - Halobenzene - Aryl bromide - Aryl halide - Monocyclic benzene moiety - Imidolactam - Benzenoid - Heteroaromatic compound - Alkanolamine - Azacycle - Organobromide - Organohalogen compound - Primary alcohol - Alcohol - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as aminopyrimidines and derivatives. These are organic compounds containing an amino group attached to a pyrimidine ring. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

CYP1A2 Tchem Cytochrome P450 1A2 (1 Activities)

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GPR119 Tclin Glucose-dependent insulinotropic receptor (1 Activities)

Discover Target: GPR119

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Zugehörige Ziele (nicht menschlich)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gpr119 Glucose-dependent insulinotropic receptor (270 Activities)

Discover Target: Gpr119

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Solvent:DMSO, Max Conc. mg/mL: 30.82, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 30.82, Max Conc. mM: 100
• Empfindlichkeit: light sensitive
• Molekulargewicht: 308.170 g/mol
• XLogP3: 2.600
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 307.032 Da
• Monoisotopic Mass: 307.032 Da
• Topological Polar Surface Area: 58.000 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 246.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1