Asiatic Acid - Moligand™,10mM in DMSO , CAS No.464-92-6

CAS: 464-92-6 Cat. No.: A408647 Molecular Weight: 488.7 EC Number: 482-720-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Dammarolic acid, Asiantic acid | Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, (2α,3β,4α)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Asiatic Acid Asiatic acid (Dammarolic acid, Asiantic acid) is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.
In vitro

In vivo

Cell Data

cell lines：Ba/F3 and HEL cells

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

Dammarolic acid, Asiantic acid | Urs-12-en-28-oic acid, 2, 3, 23-trihydroxy-, (2α, 3β, 4α)-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Asiatic acid (Dammarolic acid, Asiantic acid) is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(C[C@H]([C@@H]([C@@]5(C)CO)O)O)C)C)[C@@H]2[C@H]1C)C)C(=O)O
• WGK Germany: 3
• Molecular Weight: 488.7
• Reaxy-Rn: 3505994
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3505994&ln=

Chemical and Physical Properties

• Specific Rotation[α]: 50.3° (C=0.25,MeOH)
• Melt Point(°C): 325-330°C

References

1. Xinyu Zhu, Lijun Cai, Yu Wang, Hong Chen, Chenjie Yu, Yuanjin Zhao.  (2025)  Pollen Integrated Hydrogel Patches With Hierarchical Structures and Spatio-Temporal Actives Release for Wound Healing.  Smart Medicine,  4  (3): (e70017).  [PMID:40837201] [10.1002/smmd.70017]

2. Wenshu Zou, Minyong Zhong, Zerong Pei, Yuxin Chen, Wenwen Deng, Hui Li.  (2025)  Unveiling the neutrophil-Notch2-ISC axis: asiatic acid’s therapeutic strategy in infectious colitis.  Frontiers in Immunology,      [PMID:41058687] [10.3389/fimmu.2025.1634063]

3. Huiqiang Wei, Jianghong Guo, Xiao Sun, Wenfeng Gou, Hongxin Ning, Haihua Shang, Qiang Liu, Wenbin Hou, Yiliang Li.  (2022)  Discovery of Natural Ursane-type SENP1 Inhibitors and the Platinum Resistance Reversal Activity Against Human Ovarian Cancer Cells: A Structure–Activity Relationship Study.  JOURNAL OF NATURAL PRODUCTS,      [PMID:35500202] [10.1021/acs.jnatprod.1c01166]

4. Wenshu Zou, Kai Zhang, Zhengying Qiu, Ruihua Xin, Guibo Wang, Jingyan Zhang, Jianxi Li.  (2022)  Asiatic acid and andrographolide reduce hippocampal injury through suppressing neuroinflammation caused by Salmonella typhimurium infection.  FOOD AND CHEMICAL TOXICOLOGY,      [PMID:36581090] [10.1016/j.fct.2022.113584]

5. Wenyue Qiu, Xinting Zhang, Xiaoyue Pang, Jianjia Huang, Shuilian Zhou, Rongmei Wang, Zhaoxin Tang, Rongsheng Su.  (2022)  Asiatic acid alleviates LPS-induced acute kidney injury in broilers by inhibiting oxidative stress and ferroptosis via activation of the Nrf2 pathway.  FOOD AND CHEMICAL TOXICOLOGY,      [PMID:36244460] [10.1016/j.fct.2022.113468]

6. Mengyuan Fang, Wencui Wan, Qiuming Li, Weiwei Wan, Yang Long, Hongzhuo Liu, Xin Yang.  (2021)  Asiatic acid attenuates diabetic retinopathy through TLR4/MyD88/NF-κB p65 mediated modulation of microglia polarization.  LIFE SCIENCES,      [PMID:33965378] [10.1016/j.lfs.2021.119567]

7. Hou Yu, Zhu Lin, Ye Xiaofeng, Ke Qiaoying, Zhang Qibin, Xie Xiaowei, Piao Ji-gang, Wei Yinghui.  (2024)  Integrated oral microgel system ameliorates renal fibrosis by hitchhiking co-delivery and targeted gut flora modulation.  JOURNAL OF NANOBIOTECHNOLOGY,  22  (1): (1-21).  [PMID:38822364] [10.1186/s12951-024-02586-2]

8. Jiang Qianqian, Fan Guoxia, Wu Kaiwei.  (2024)  Potential Action Mechanism of Erianin in Relieving MNNG-triggered Chronic Atrophic Gastritis.  CELL BIOCHEMISTRY AND BIOPHYSICS,      [PMID:39298066] [10.1007/s12013-024-01536-x]

9. Yicong Zhang, Yujia Wang, Hanming Zhang, Shiqi Huang, Yuai Li, Jiaying Long, Yikun Han, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang.  (2024)  Replacing cholesterol with asiatic acid to prolong circulation and enhance anti-metastatic effects of non-PEGylated liposomes.  JOURNAL OF CONTROLLED RELEASE,      [PMID:38215987] [10.1016/j.jconrel.2024.01.009]

10. Caiying Wang, Yue Zhang, Yabin Lu, Xin Huang, Huazheng Jiang, Guohui Chen, Yongheng Shao, Huub F.J. Savelkoul, Christine A. Jansen, Guangliang Liu.  (2024)  TGF-β1 impairs IgA class switch recombination and production in porcine Peyer's patches B cells.  EUROPEAN JOURNAL OF IMMUNOLOGY,      [PMID:38973082] [10.1002/eji.202350704]

11. Jiaqi Wu, Guizhen Xu, Xinlu Zhou, Jun Wan, Huaiwei Liao, Cong Li, Yan Shi, Huicai Wen.  (2025)  Asiatic Acid Inhibits Keloid Fibroblast Migration and Collagen Deposition via Suppression of STAT3 Activation.  BURNS,      [PMID:40700781] [10.1016/j.burns.2025.107586]

12. Lei Guo, Peili Wu, Qijian Feng, Xiaochun Lin, Yuan Wang, Minghai Wu, Feifei Cai, Jin Zhang, Chuyi Yang, Xuelin Li, Churan Wen, Yingbei Lin, Nannan Liu, Yuxuan Hu, Huiyun Wang, Xinzhao Fan, Meiping Guan.  (2025)  Asiatic Acid Alleviates Renal Damage by Upregulating STBD1-Mediated Glycophagy in Diabetic Kidney Disease.  Biomedicines,  13  (7): (1544).  [PMID:40722620] [10.3390/biomedicines13071544]

13. Yuhan Yang, Yanlin Zhu, Hongyan Yuan, Zun Yang, Jie Zhou.  (2026)  Asiatic Acid-Loaded Hydrogel Ameliorates Diabetic Periodontitis via Mitophagy-Mediated M2 Macrophage Polarization.  ACS Omega,      [PMID:41768656] [10.1021/acsomega.5c11543]

14. Huan Liu, Liying Liang, Minggang Wang, Qinfeng Huang, Yu Pan, Xiaojie Wei, Wenchao Zhang.  (2026)  Establishment of a Novel Monoclonal Antibody Based icELISA Method to Determine the Total Content of Ursolic and Oleanolic Acids in Fruits.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,      [PMID:] [10.1016/j.jfca.2026.109072]