Atglistatin - 10mM in DMSO , CAS No.1469924-27-3

CAS: 1469924-27-3 Cat. No.: A421712 Summenformel: C₁₇H₂₁N₃O Molekulargewicht: 283.37 EG-Nummer: 809-205-7

GRADE & PURITY 10mM in DMSO

Synonyms

AKOS026750242 | HY-15859 | FT-0700208 | SW220102-1 | AC-35213 | EN300-172737 | 3-(4'-(dimethylamino)biphenyl-3-yl)-1,1-dimethylurea | s7364 | AWOPBSAJHCUSAS-UHFFFAOYSA-N | NCGC00261484-01 | 1-[4'-(DIMETHYLAMINO)-[1,1'-BIPHENYL]-3-YL]-3,3-DIMETHYLUREA | 3-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

Synonyme

AKOS026750242 | HY-15859 | FT-0700208 | SW220102-1 | AC-35213 | EN300-172737 | 3-(4'-(dimethylamino)biphenyl-3-yl)-1,1-dimethylurea | s7364 | AWOPBSAJHCUSAS-UHFFFAOYSA-N | NCGC00261484-01 | 1-[4'-(DIMETHYLAMINO)-[1,1'-BIPHENYL]-3-YL]-3,3-DIMETHYLUREA | 3-

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Atglistatin is the first drug to selectively inhibit adipotriglyceride lipase (ATGL), a rate limiting enzyme involved in the mobilization of fatty acids from cellular triglyceride stores. The IC50 of atglistatin was 0.7 μ m in E. coli, and it had no activ

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Namen und Kennungen

• Pubchem Sid: 528763333
• Kanonisches Lächeln: CN(C)C1=CC=C(C=C1)C2=CC(=CC=C2)NC(=O)N(C)C
• IUPAC Name: 3-[3-[4-(dimethylamino)phenyl]phenyl]-1,1-dimethylurea
• InChIKey: AWOPBSAJHCUSAS-UHFFFAOYSA-N
• INCHI: 1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)
• Isomere SMILES: CN(C)C1=CC=C(C=C1)C2=CC(=CC=C2)NC(=O)N(C)C
• Molekulargewicht: 283.37
• Reaxy-Rn: 29267490
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29267490&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Biphenyls and derivatives
• Alternative Parents: N-phenylureas Dialkylarylamines Aniline and substituted anilines Ureas Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Biphenyl - N-phenylurea - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aniline or substituted anilines - Tertiary amine - Urea - Amine - Organic oxide - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Hydrocarbon derivative - Aromatic homomonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

PNPLA2 Tchem Patatin-like phospholipase domain-containing protein 2 (1 Activities)

Discover Target: PNPLA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Zugehörige Ziele (nicht menschlich)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pnpla2 Patatin-like phospholipase domain-containing protein 2 (302 Activities)

Discover Target: Pnpla2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Molekulargewicht: 283.370 g/mol
• XLogP3: 3.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 283.168 Da
• Monoisotopic Mass: 283.168 Da
• Topological Polar Surface Area: 35.600 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 335.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referenzen

1. Jian Chen, Zhixiang Wei, Zixuan Song, Sitong Meng, Jiaqi An, Zhenqun Zhang, Yaning Biao, Muqing Zhang, Yixin Zhang.  (2026)  Atractylodin ameliorates obesity-associated hepatic steatosis by regulating the PLIN2-ATGL/CPT1A axis-mediated lipid droplet-mitochondria interactions.  PHYTOMEDICINE,      [PMID:41936174] [10.1016/j.phymed.2026.158134]

2. Min Zhou, Xiaojing Zhao, Zixuan Yang, Lihui Meng, Zhaozhe Xin, Sijia Xue, Jinyong Zhang.  (2026)  Ameson portunus ACSL mediates host fatty acid acquisition for intracellular proliferation.  Water Biology and Security,      [PMID:] [10.1016/j.watbs.2026.100699]