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Atuveciclib - ≥99% , CAS No.A658632
AVAILABLE TO ORDER
GRADE & PURITY ≥99%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor. Atuveciclib (BAY-1143572) inhibits CDK9 / CycT1 with an IC 50 of 13 nM.
Appearance:Solid
IC50& Target:CDK9/CycT1 13 nM (IC 50 ) CDK9/CycT1(h) 6 nM (IC 50 ) CDK3/CycE(h) 890 nM (IC 50 ) CDK2/CycE(h) 1000 nM (IC 50 ) CDK1/CycB(h) 1100 nM (IC 50 ) CDK5/p35(h) 1600 nM (IC 50 )
In Vitro:Positive transcription elongation factor b (PTEFb) is a heterodimer of CDK9 and one of four cyclin partners, cyclin T1, cyclin K, cyclin T2a or cyclin T2b. Atuveciclib (BAY-1143572) demonstrates potent antiproliferative activity against HeLa cells (IC 50
In Vivo:In vivo efficacy studies in the MOLM-13 xenograft model in mice, Atuveciclib (BAY-1143572) demonstrates great potency and high antitumor efficacy. Daily administration of Atuveciclib (BAY-1143572) at 6.25 or 12.5mg/kg results in a dose-dependent antitumo
Biological Activity:Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor. Atuveciclib (BAY-1143572) inhibits CDK9 / CycT1 with an IC 50 of 13 nM.
Specifications
Specifications & Purity
≥99%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥99%
Names and Identifiers
| Molecular Weight | 387.43 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : ≥ 128.5 mg/mL (331.67 mM) |
|---|
Solution Calculators
Reviews
Customer Reviews
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