Azacyclonol - 10mM in DMSO , CAS No.115-46-8

CAS: 115-46-8 Cat. No.: A408482 Summenformel: C₁₈H₂₁NO Molekulargewicht: 267.37 Beilstein Registry Number: 21(5)4,72 EG-Nummer: 204-092-5

QUALITÄT & REINHEIT 10mM in DMSO

Synonyms

MER 17, MDL 4829 | 4-(Diphenylhydroxymethyl)piperidine

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Azacyclonol (MER 17, MDL 4829), also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.
In vitro

The formation of Azacyclonol in human intestinal microsomes is linear with respect to time up to 60 min. The rates of formation of Azacyclonol increases linearly with microsomal protein concentration up to 2 mg/mL. The apparent Km and Vmax values of Azacyclonol are 0.82 μM and 60 pmol/min/mg protein in microsomes from human liver. The formation of Azacyclonol and terfenadine alcohol from terfenadine is confirmed to be catalyzed predominantly by CYP3A(4) isozyme, and the ratio of the rate of terfenadine alcohol formation to that of Azacyclonol is 3:1. The amount of Azacyclonol eliminated renally increases on average 2-fold after rifampin dosing.

In vivo

Azacyclonol (i.v.) impairs the response of the nictitating membrane to both post- and preganglionic stimulation. The activity of Azacyclonol in depressing transmission through the cat superior ceivical ganglion is 6.63%.
Cell Data

cell lines：HCT116 cells and HCT116 TP53^-/- cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Spezifikationen

Synonyme

MER 17, MDL 4829 | 4-(Diphenylhydroxymethyl)piperidine

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Azacyclonol (MER 17, MDL 4829), also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Isomere SMILES

C1CNCCC1C(C2=CC=CC=C2)(C3=CC=CC=C3)O

RTECS

TN0470000

Molekulargewicht

267.37

Beilstein

21(5)4,72

Reaxy-Rn

230221

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=230221&ln=

Chemische und physikalische Eigenschaften

• Schmelzpunkt (°C): 163 °C