≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2 , with an EC 50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1 , 3, 4, 5, 6, 7, and 8 subtypes
In Vitro
AZD-8529 mesylate potentiates the effects of glutamate at mGluR2 with an EC 50 of 195 nM. AZD-8529 mesylate does not elicit antagonist responses on mGluRs at 25 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
AZD-8529 mesylate (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys . AZD-8529 mesylate (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Sprague-Dawley rats Dosage: 10 mg/kg, 30 mg/kg Administration: Intraperitoneal injection; 2 hours before nicotine injections Result: Decreased the increased extracellular dopamine induced by nicotine (0.4 mg/kg, s.c.) in accumbens shell of freely-moving rats.
Form:Solid
IC50& Target:mGluR2 285 nM (EC 50 )
| Kanonisches Lächeln | CC1=CC(=CC2=C1C(=O)N(C2)CC3=CC=C(C=C3)OC(F)(F)F)C4=NC(=NO4)CN5CCNCC5.CS(=O)(=O)O |
|---|---|
| IUPAC Name | methanesulfonic acid;7-methyl-5-[3-(piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]-2-[[4-(trifluoromethoxy)phenyl]methyl]-3H-isoindol-1-one |
| InChIKey | HRHCPVNKPOTCGB-UHFFFAOYSA-N |
| INCHI | 1S/C24H24F3N5O3.CH4O3S/c1-15-10-17(22-29-20(30-35-22)14-31-8-6-28-7-9-31)11-18-13-32(23(33)21(15)18)12-16-2-4-19(5-3-16)34-24(25,26)27;1-5(2,3)4/h2-5,10-11,28H,6-9,12-14H2,1H3;1H3,(H,2,3,4) |
| Isomere SMILES | CC1=CC(=CC2=C1C(=O)N(C2)CC3=CC=C(C=C3)OC(F)(F)F)C4=NC(=NO4)CN5CCNCC5.CS(=O)(=O)O |
| Alternative CAS-Nummer | 1314217-69-0 |
| PubChem CID | 53495155 |
| Molekulargewicht | 583.6 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Klasse | Isoindoles and derivatives |
| Subclass | Isoindolines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Isoindolones |
| Alternative Parents | Isoindoles Phenoxy compounds Phenol ethers Aralkylamines N-alkylpiperazines Tertiary carboxylic acid amides Sulfonyls 1,2,4-oxadiazoles Organosulfonic acids Alkanesulfonic acids Heteroaromatic compounds Methanesulfonates Trihalomethanes Trialkylamines Amino acids and derivatives Lactams Oxacyclic compounds Azacyclic compounds Dialkylamines Organopnictogen compounds Organofluorides Organooxygen compounds Alkyl fluorides Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Not available |
| Substituents | Isoindolone - Isoindole - Phenoxy compound - Phenol ether - N-alkylpiperazine - Aralkylamine - Monocyclic benzene moiety - 1,4-diazinane - Piperazine - Benzenoid - Methanesulfonate - Oxadiazole - 1,2,4-oxadiazole - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Organosulfonic acid - Heteroaromatic compound - Azole - Alkanesulfonic acid - Tertiary carboxylic acid amide - Sulfonyl - Tertiary aliphatic amine - Lactam - Tertiary amine - Amino acid or derivatives - Trihalomethane - Carboxamide group - Azacycle - Oxacycle - Secondary amine - Carboxylic acid derivative - Secondary aliphatic amine - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Alkyl fluoride - Amine - Hydrocarbon derivative - Alkyl halide - Halomethane - Organic oxide - Organosulfur compound - Organohalogen compound - Organofluoride - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound |
| Beschreibung | This compound belongs to the class of organic compounds known as isoindolones. These are aromatic polycyclic compounds that an isoindole bearing a ketone. |
| External Descriptors | Not available |
| Löslichkeit | DMSO : 41.67 mg/mL (71.40 mM; Need ultrasonic) |
|---|---|
| Molekulargewicht | 583.600 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 13 |
| Rotatable Bond Count | 6 |
| Exact Mass | 583.171 Da |
| Monoisotopic Mass | 583.171 Da |
| Topological Polar Surface Area | 146.000 Ų |
| Heavy Atom Count | 40 |
| Formal Charge | 0 |
| Complexity | 822.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
