AZD3229 Tosylate - ≥99% , CAS No.2248003-71-4

CAS: 2248003-71-4 Cat. No.: A647647 Summenformel: C₃₁H₃₄FN₇O₆S Molekulargewicht: 651.71 PubChem CID: 135367697

GRADE & PURITY ≥99%

Synonyms

YPD00371 | MS-30968 | A16867 | N-[4-[[5-fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yltriazol-1-yl)acetamide;4-methylbenzenesulfonic acid | 2248003-71-4 | HY-112802A | SCHEMBL20547018 | AZD3229 Tosylate

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Übersicht

AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.

In Vitro

AZD3229 is a potent, pan-KIT mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI 50 =1-50 nM). AZD3229 demonstrates potent single digit nM growth inhibition across a broad cell panel, with good margin to KDR-driven effects. Selectivity over KDR can be rationalised predominantly by the interaction of water molecules with the protein and ligand in the active site and its kinome selectivity is similar to the best of the approved GIST agents. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:KIT

Specifications

Synonyme

YPD00371 | MS-30968 | A16867 | N-[4-[[5-fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yltriazol-1-yl)acetamide;4-methylbenzenesulfonic acid | 2248003-71-4 | HY-112802A | SCHEMBL20547018 | AZD3229 Tosylate

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.

Storage

Store at 2-8°C,Desiccated

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥99%

Namen und Kennungen

Kanonisches Lächeln

CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)C1=CN(N=N1)CC(=O)NC2=CC=C(C=C2)NC3=NC=NC4=C3C(=CC(=C4)OCCOC)F

IUPAC Name

N-[4-[[5-fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yltriazol-1-yl)acetamide;4-methylbenzenesulfonic acid

InChIKey

AWHHAHZPRULJMA-UHFFFAOYSA-N

INCHI

1S/C24H26FN7O3.C7H8O3S/c1-15(2)21-12-32(31-30-21)13-22(33)28-16-4-6-17(7-5-16)29-24-23-19(25)10-18(35-9-8-34-3)11-20(23)26-14-27-24;1-6-2-4-7(5-3-6)11(8,9)10/h4-7,10-12,14-15H,8-9,13H2,1-3H3,(H,28,33)(H,26,27,29);2-5H,1H3,(H,8,9,10)

Isomere SMILES

CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)C1=CN(N=N1)CC(=O)NC2=CC=C(C=C2)NC3=NC=NC4=C3C(=CC(=C4)OCCOC)F

Alternative CAS-Nummer

2248003-71-4

PubChem CID

135367697

Molekulargewicht

651.71

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : ≥ 100 mg/mL (153.44 mM)

Häufig gestellte Fragen

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2248003-71-4, the molecular formula is C31H34FN7O6S, and the molecular weight is 651.71 g/mol. InChIKey AWHHAHZPRULJMA-UHFFFAOYSA-N.

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.