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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
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Why this grade
Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Übersicht
AZD4694 (NAV4694), a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils ( K d = 2.3 nM)
In Vivo
Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue . AZD4694 (4 mL/kg; intravenous injection) inhibits [ 3 H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague–Dawley rats (275-300 g) Dosage: 4 mL/kg Administration: I.v. Result: Inhibited [ 3 H]AZD2184 binding in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients.
Form:Solid
IC50& Target:Kd: 2.3 nM (Aβ)
Specifications
Spezifikationen & Reinheit
Moligand™, ≥98%
Biochemische und physiologische Mechanismen
AZD4694 (NAV4694), a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils ( K d = 2.3 nM).
Storage
Store at -20°C
Verschickt in
Ice chest + Ice pads
Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.
Note
Moligand™
Aktionsart
ACTIVATOR
Reinheit
≥98%
Namen und Kennungen
| Isomere SMILES | CNC1=NC(=C(C=C1)C2=CC3=C(O2)C=CC(=C3)O)F |
|---|---|
| PubChem CID | 24896605 |
| Molekulargewicht | 258.25 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Zugehörige Ziele (menschlich)
APP Tclin Amyloid-beta A4 protein (1 Activities)
Wirkungsmechanismen
Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemische und physikalische Eigenschaften
| Löslichkeit | DMSO : 100 mg/mL (387.22 mM; Need ultrasonic) |
|---|---|
| Molekulargewicht | 258.250 g/mol |
| XLogP3 | 3.300 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 2 |
| Exact Mass | 258.08 Da |
| Monoisotopic Mass | 258.08 Da |
| Topological Polar Surface Area | 58.300 Ų |
| Heavy Atom Count | 19 |
| Formal Charge | 0 |
| Complexity | 318.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
Lösungsrechner
Bewertungen
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Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
View Moligand™ grade guide →Verwandte Produkte
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