AZD7687 - Moligand™, ≥98% , Inhibitor of diacylglycerol O-acyltransferase 1, CAS No.1166827-44-6, Inhibitor of diacylglycerol O-acyltransferase 1

CAS: 1166827-44-6 Cat. No.: A128057 Summenformel: C₂₁H₂₅N₃O₃ Molekulargewicht: 367.44 EG-Nummer: 682-438-8

GRADE & PURITY Moligand™, ≥98%

Synonyms

AZD7687 | AZD-7687 | DB14949 | 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl]acetic acid | SCHEMBL5532381 | AZD 7687 | GTPL7827 | AKOS030526281 | 6QTJ9P2NYT | AZD 7687 [WHO-DD] | EN300-16131 | NCGC00378858-01 | SCHEMBL2252415 | 1166827-4

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyme

AZD7687 | AZD-7687 | DB14949 | 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl]acetic acid | SCHEMBL5532381 | AZD 7687 | GTPL7827 | AKOS030526281 | 6QTJ9P2NYT | AZD 7687 [WHO-DD] | EN300-16131 | NCGC00378858-01 | SCHEMBL2252415 | 1166827-4

Spezifikationen & Reinheit

Moligand™, ≥98%

Biochemische und physiologische Mechanismen

The attenuating effect of AZD7687, the selective DGAT1 inhibitor, on postprandial triacylglycerol (TAG) excursion provides proof of mechanism with respect to gut DGAT1 inhibition. Nausea, vomiting and diarrhoea were reported with increasi

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Inhibitor of diacylglycerol O-acyltransferase 1

Reinheit

≥98%

Namen und Kennungen

• Kanonisches Lächeln: CC1=C(N=C(C(=N1)C)C(=O)N)C2=CC=C(C=C2)C3CCC(CC3)CC(=O)O
• IUPAC Name: 2-[4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl]acetic acid
• InChIKey: YXFNPRHZMOGREC-UHFFFAOYSA-N
• INCHI: 1S/C21H25N3O3/c1-12-19(24-20(21(22)27)13(2)23-12)17-9-7-16(8-10-17)15-5-3-14(4-6-15)11-18(25)26/h7-10,14-15H,3-6,11H2,1-2H3,(H2,22,27)(H,25,26)
• Isomere SMILES: CC1=C(N=C(C(=N1)C)C(=O)N)C2=CC=C(C=C2)C3CCC(CC3)CC(=O)O
• Molekulargewicht: 367.44
• Reaxy-Rn: 35562638
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=35562638&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Diazines
      • Subclass Pyrazines
        • Ebene5 Pyrazine carboxylic acids and derivatives
          • Ebene6 Pyrazinecarboxamides

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Diazines
• Subclass: Pyrazines
• Intermediate Tree Nodes: Pyrazine carboxylic acids and derivatives
• Direct Parent: Pyrazinecarboxamides
• Alternative Parents: 2-heteroaryl carboxamides Benzene and substituted derivatives Heteroaromatic compounds Primary carboxylic acid amides Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyrazinecarboxamide - 2-heteroaryl carboxamide - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Carboxamide group - Primary carboxylic acid amide - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Azacycle - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Carbonyl group - Hydrocarbon derivative - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as pyrazinecarboxamides. These are compounds containing a pyrazine ring which bears a carboxamide.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

DGAT1 Tclin Diacylglycerol O-acyltransferase 1 (5 Activities)

Discover Target: DGAT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO
• Molekulargewicht: 367.400 g/mol
• XLogP3: 3.200
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 367.19 Da
• Monoisotopic Mass: 367.19 Da
• Topological Polar Surface Area: 106.000 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 525.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1