BC-1215 - 10mM in DMSO , CAS No.1507370-20-8

CAS: 1507370-20-8 Cat. No.: B421778 Summenformel: C₂₆H₂₆N₄ Molekulargewicht: 394.51 EG-Nummer: 808-501-3

GRADE & PURITY 10mM in DMSO

Synonyms

AKOS037643445 | EX-A4964 | C26H26N4 | S0322 | N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine | N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine | AS-16457 | A900369 | AT11446 | HY-117937 | BC1215 | BC-1215 | N,N'-Bis[(4-pyridin-2-ylphenyl)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

BC-1215 is an inhibitor of F-box protein 3 (Fbxo3, a ubiquitin E3 ligase component) with IC50 of 0.9 μg/mL and LC50 of 87 μg/ml for IL-1β release. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1-6.

Targets

IL-1β release (Cell-free assay); IL-1β release (Cell-free assay) 0.9 μg/mL; 87 μg/mL(LC50)

Specifications

Synonyme

AKOS037643445 | EX-A4964 | C26H26N4 | S0322 | N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine | N1,N2-Bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine | AS-16457 | A900369 | AT11446 | HY-117937 | BC1215 | BC-1215 | N,N'-Bis[(4-pyridin-2-ylphenyl)

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

BC-1215 is an inhibitor of F-box protein 3 (Fbxo3, a ubiquitin E3 ligase component) with IC50 of 0.9 μg/mL and LC50 of 87 μg/ml for IL-1β release. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1-6.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

• Pubchem Sid: 528763395
• Kanonisches Lächeln: C1=CC=NC(=C1)C2=CC=C(C=C2)CNCCNCC3=CC=C(C=C3)C4=CC=CC=N4
• IUPAC Name: N,N'-bis[(4-pyridin-2-ylphenyl)methyl]ethane-1,2-diamine
• InChIKey: IXEPQJQQSLMESJ-UHFFFAOYSA-N
• INCHI: 1S/C26H26N4/c1-3-15-29-25(5-1)23-11-7-21(8-12-23)19-27-17-18-28-20-22-9-13-24(14-10-22)26-6-2-4-16-30-26/h1-16,27-28H,17-20H2
• Isomere SMILES: C1=CC=NC(=C1)C2=CC=C(C=C2)CNCCNCC3=CC=C(C=C3)C4=CC=CC=N4
• WGK Deutschland: 3
• Molekulargewicht: 394.51
• Reaxy-Rn: 24671086
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24671086&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Pyridines and derivatives
      • Subclass Phenylpyridines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Pyridines and derivatives
• Subclass: Phenylpyridines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyridines
• Alternative Parents: Phenylmethylamines Benzylamines Aralkylamines Heteroaromatic compounds Dialkylamines Azacyclic compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: 2-phenylpyridine - Phenylmethylamine - Benzylamine - Aralkylamine - Benzenoid - Monocyclic benzene moiety - Heteroaromatic compound - Azacycle - Secondary amine - Secondary aliphatic amine - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Amine - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

U-937 (7138 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Zugehörige Ziele (nicht menschlich)

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Molekulargewicht: 394.500 g/mol
• XLogP3: 3.500
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 394.216 Da
• Monoisotopic Mass: 394.216 Da
• Topological Polar Surface Area: 49.800 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 412.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1