BEC HCl - ≥98% , CAS No.222638-67-7

CAS: 222638-67-7 Cat. No.: B413875 Summenformel: C₅H₁₂BNO₄S.HCl Molekulargewicht: 229.49 EG-Nummer: 110-433-8 PubChem CID: 91826515

QUALITÄT & REINHEIT ≥98%

Synonyms

BCP25043 | BEC HCl | (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid hydrochloride | BEC hydrochloride | A900880 | XIA63867 | AC-29891 | AKOS030632996 | (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid;hydrochloride | S-(2-Boronoethyl)-l-cysteine

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Übersicht

Information

BEC HCl BEC HCl is a slow-binding, and competitive arginase inhibitor with K i of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.

Targets

Arginase II ; rat Arginase I 0.31 μM(Ki); <0.6 μM(Ki)

In vitro

BEC causes significant enhancement of NO-dependent smooth muscle relaxation. In myocytes, BEC augments Ca(2+)-dependent NOS activity and NO production, and increases basal contractility. BEC also inhibits the proliferation of human pulmonary artery smooth muscle cells by decreasing the expression levels of cyclin D1 and CDK4, increasing the expression of p27, and partly reducing the phosphorylation of Akt and ERK.

In vivo

In mice with allergic inflammation (OVA/OVA), BEC enhances peribronchiolar and perivascular inflammation, leads to enhanced NF-κB DNA binding and NF-κB-dependent inflammatory gene expression, and causes an increase in the content of NOx. In rats with pulmonary arterial hypertension, BEC reduces the right ventricle systolic pressure.

Spezifikationen

Synonyme

BCP25043 | BEC HCl | (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid hydrochloride | BEC hydrochloride | A900880 | XIA63867 | AC-29891 | AKOS030632996 | (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid;hydrochloride | S-(2-Boronoethyl)-l-cysteine

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

BEC HCl is a slow-binding, and competitive arginase inhibitor with K_i of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.

Storage

Store at -20°C,Argon charged

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥98%

Produkteigenschaften

ALogP

-2.415

Rotationsfähige Bindung

6

Namen und Kennungen

Pubchem Sid

504772680

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504772680

Kanonisches Lächeln

B(CCSCC(C(=O)O)N)(O)O.Cl

IUPAC Name

(2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid;hydrochloride

InChIKey

GHPYJLCQYMAXGG-WCCKRBBISA-N

INCHI

1S/C5H12BNO4S.ClH/c7-4(5(8)9)3-12-2-1-6(10)11;/h4,10-11H,1-3,7H2,(H,8,9);1H/t4-;/m0./s1

Isomere SMILES

B(CCSC[C@@H](C(=O)O)N)(O)O.Cl

PubChem CID

91826515

Molekulargewicht

229.49

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Klasse Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Ebene5 Amino acids and derivatives
          • Ebene6 Alpha amino acids and derivatives
            • Ebene7 Cysteine and derivatives
              • Ebene8 L-cysteine-S-conjugates

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Klasse: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives - Cysteine and derivatives
• Direct Parent: L-cysteine-S-conjugates
• Alternative Parents: L-alpha-amino acids Boronic acids Amino acids Sulfenyl compounds Organic metalloid salts Monocarboxylic acids and derivatives Dialkylthioethers Carboxylic acids Organic oxides Monoalkylboranes Monoalkylamines Hydrochlorides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: L-cysteine-s-conjugate - Alpha-amino acid - L-alpha-amino acid - Boronic acid derivative - Boronic acid - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Thioether - Sulfenyl compound - Dialkylthioether - Organic metalloid salt - Organic oxygen compound - Amine - Primary amine - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic metalloid moeity - Organic nitrogen compound - Primary aliphatic amine - Monoalkylborane - Hydrochloride - Carbonyl group - Alkylborane - Hydrocarbon derivative - Organic oxide - Aliphatic acyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as l-cysteine-s-conjugates. These are compounds containing L-cysteine where the thio-group is conjugated.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 45 mg/mL (196.08 mM); Water: 45 mg/mL (196.08 mM); Ethanol: 45 mg/mL (196.08 mM)
• DMSO (mg/ml) Maximale Löslichkeit: 45
• DMSO (mM) Maximale Löslichkeit: 196.0869755
• Wasser (mg/ml) Maximale Löslichkeit: 45
• Wasser (mM) Maximale Löslichkeit: 196.0869755
• Molekulargewicht: 229.490 g/mol
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 229.035 Da
• Monoisotopic Mass: 229.035 Da
• Topological Polar Surface Area: 129.000 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 145.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3