Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 17 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Bezafibrate is the first clinically tested dual and pan-PPAR co-agonism.
A peroxisome proliferator and hypolipidaemic agent.
| ALogP | 3.8 |
|---|
| Canonical Smiles | CC(C)(C(=O)O)OC1=CC=C(C=C1)CCNC(=O)C2=CC=C(C=C2)Cl |
|---|---|
| IUPAC Name | 2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid |
| InChIKey | IIBYAHWJQTYFKB-UHFFFAOYSA-N |
| INCHI | 1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24) |
| Isomeric SMILES | CC(C)(C(=O)O)OC1=CC=C(C=C1)CCNC(=O)C2=CC=C(C=C2)Cl |
| WGK Germany | 1 |
| RTECS | UE8755000 |
| Molecular Weight | 361.82 |
| Reaxy-Rn | 4267656 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4267656&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Class | Benzene and substituted derivatives |
| Subclass | Phenoxyacetic acid derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Phenoxyacetic acid derivatives |
| Alternative Parents | 4-halobenzoic acids and derivatives Benzamides Phenoxy compounds Phenol ethers Benzoyl derivatives Alkyl aryl ethers Chlorobenzenes Aryl chlorides Secondary carboxylic acid amides Monocarboxylic acids and derivatives Carboxylic acids Carbonyl compounds Hydrocarbon derivatives Organic oxides Organochlorides Organonitrogen compounds Organopnictogen compounds |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Phenoxyacetate - 4-halobenzoic acid or derivatives - Halobenzoic acid or derivatives - Benzoic acid or derivatives - Benzamide - Phenoxy compound - Phenol ether - Benzoyl - Chlorobenzene - Alkyl aryl ether - Halobenzene - Aryl chloride - Aryl halide - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Ether - Organic nitrogen compound - Organohalogen compound - Organochloride - Organonitrogen compound - Carbonyl group - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as phenoxyacetic acid derivatives. These are compounds containing an anisole where the methane group is linked to an acetic acid or a derivative. |
| External Descriptors | aromatic ether - monocarboxylic acid - monocarboxylic acid amide - monochlorobenzenes |
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| Melt Point(°C) | 183-186°C |
|---|---|
| Molecular Weight | 361.800 g/mol |
| XLogP3 | 3.800 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 7 |
| Exact Mass | 361.108 Da |
| Monoisotopic Mass | 361.108 Da |
| Topological Polar Surface Area | 75.600 Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 452.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Huimin Zhou, Zhiwei Qiu, Jin Zeng, Ruobin Dai, Zhiwei Wang. (2023) Ultra-permeable polyamide nanofiltration membrane modified by hydrophilic-hydrophobic alternated lignocellulosic nanofibrils for efficient water reuse. JOURNAL OF MEMBRANE SCIENCE, [PMID:] [10.1016/j.memsci.2023.122125] |
| 2. Xuecong Qian, Shilong Wang, Haijun Cheng, Ziye Jia, Da Wang, Yandong Xie, Jinhao Duan, Yu Tian, Jun Ma. (2023) Mn(II) oxidation by the UV/chlorine system under near-neutral pH conditions: The important role of ClO· and ClO2. WATER RESEARCH, [PMID:37844341] [10.1016/j.watres.2023.120673] |
| 3. Mingming Qi, Hui Zhong, Zhaoyan Cheng, Shujie Chen, Han Xiao, Jing Shang, Li Chen, Jianbo Sun. (2023) Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1. JOURNAL OF MEDICINAL CHEMISTRY, [PMID:37386884] [10.1021/acs.jmedchem.3c00822] |
| 4. Tianhua He, Nikita Lykov, Xu Luo, Huiling Wang, Zhanxiang Du, Ziyi Chen, Shitian Chen, Lin Zhu, Ye Zhao, Chimeng Tzeng. (2023) Protective Effects of Lactobacillus gasseri against High-Cholesterol Diet-Induced Fatty Liver and Regulation of Host Gene Expression Profiles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (3): (2053). [PMID:36768377] [10.3390/ijms24032053] |
| 5. Ji Ma, Yang Deng, Tingting Yang, Maoru Li, Jing Shang. (2023) Esculetin Alleviates Nonalcoholic Fatty Liver Disease on High-Cholesterol-Diet-Induced Larval Zebrafish and FFA-Induced BRL-3A Hepatocyte. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (2): (1593). [PMID:36675107] [10.3390/ijms24021593] |
| 6. Hui Su, Xudan Dou, Dandan Xu, Li Feng, Yongze Liu, Ziwen Du, Liqiu Zhang. (2022) Fe0-loaded superfine powdered activated carbon prepared by ball milling for synergistic adsorption and persulfate activation to remove aqueous carbamazepine. CHEMOSPHERE, [PMID:35051510] [10.1016/j.chemosphere.2022.133665] |
| 7. Xiangyu Chen, Juanjuan Yao, Hongsen Dong, Mingjian Hong, Naiyun Gao, Zhi Zhang, Wenchao Jiang. (2021) Enhanced bezafibrate degradation and power generation via the simultaneous PMS activation in visible light photocatalytic fuel cell. WATER RESEARCH, [PMID:34741902] [10.1016/j.watres.2021.117800] |
| 8. Yang Deng, Ji Ma, Xin Weng, Yuqin Wang, Maoru Li, Tingting Yang, Zhiyang Dou, Zhiqi Yin, Jing Shang. (2021) Kaempferol-3-O-Glucuronide Ameliorates Non-Alcoholic Steatohepatitis in High-Cholesterol-Diet-Induced Larval Zebrafish and HepG2 Cell Models via Regulating Oxidation Stress. Life-Basel, 11 (5): (445). [PMID:34069176] [10.3390/life11050445] |
| 9. Yang Guo, Erzhuo Zhao, Jun Wang, Xiaoyuan Zhang, Haiou Huang, Gang Yu, Yujue Wang. (2019) Comparison of emerging contaminant abatement by conventional ozonation, catalytic ozonation, O3/H2O2 and electro-peroxone processes. JOURNAL OF HAZARDOUS MATERIALS, [PMID:31836369] [10.1016/j.jhazmat.2019.121829] |
| 10. Nadeem Muhammad, Dandan Guo, Yun Zhang, Azeem Intisar, Qamar Subhani, Muhammad Abdul Qadir, Hairong Cui. (2019) Online clean-up setup for the determination of non-fluorescent acidic pharmaceutical drugs in complex biological samples. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, [PMID:31437773] [10.1016/j.jchromb.2019.06.035] |
| 11. Ji Ma, Hongli Yin, Maoru Li, Yang Deng, Owais Ahmad, Guohong Qin, Qiangqiang He, Jiajing Li, Kai Gao, Junyi Zhu, Bing Wang, Susu Wu, Tao Wang, Jing Shang. (2019) A Comprehensive Study of High Cholesterol Diet-Induced Larval Zebrafish Model: A Short-Time In Vivo Screening Method for Non-Alcoholic Fatty Liver Disease Drugs. International Journal of Biological Sciences, [PMID:31182918] [10.7150/ijbs.30013] |
| 12. Shen Chang-shuai, Zhou Cai-rong. (2016) Investigation of the thermal decomposition kinetics of bezafibrate. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 126 (2): (959-967). [PMID:] [10.1007/s10973-016-5565-9] |
| 13. Gao Yu-qiong, Ma Jia-xin, Rao Yan-yan, Chen Ju-xiang, Gao Nai-yun. (2024) Efficient Degradation of Bezafibrate Using the Fe(II)/Sulfite Process: Kinetics, Mechanism and Influence on DBP Formation. International Journal of Environmental Research, 18 (6): (1-16). [PMID:] [10.1007/s41742-024-00658-7] |
| 14. Yuqiong Gao, Kexuan Li, Xiangmei Zhong, Han Ning. (2024) Electro-Assisted Fe3+/Persulfate System for the Degradation of Bezafibrate in Water: Kinetics, Degradation Mechanism, and Toxicity. Water, 16 (5): (649). [PMID:] [10.3390/w16050649] |
| 15. Zekun Dong, Jie Yao, Zhihui Hu, Jiao Yang, Yan Zhang. (2024) Insight into roles of carbon anodes for removal of refractory organic contaminants in electro-peroxone system: Mechanism, performance and stability. JOURNAL OF HAZARDOUS MATERIALS, [PMID:38452678] [10.1016/j.jhazmat.2024.133957] |
| 16. Xiangyu Chen, Hao Zhong, Juanjuan Yao, Jingye Gan, Haibing Cong, Tengyi Zhu. (2025) Photocatalytic Degradation of Typical Fibrates by N and F Co-Doped TiO2 Nanotube Arrays Under Simulated Sunlight Irradiation. Water, 17 (15): (2261). [PMID:] [10.3390/w17152261] |
| 17. Ren Yuanyuan, Cui Yue, Wang Zhen, Luo Yizhi, Jin Junchang, Yuan Yiyi, Li Xuan, Zhang Yaning, Cao Nan, Li Xiaofang, Yu Yi, Xiong Yuyan. (2025) ALDH3A2 negatively orchestrates gastric cancer progression through a synergistic induction of ferroptosis and ferroptosis-driven macrophage reprogramming. Cell Death & Disease, [PMID:41444219] [10.1038/s41419-025-08364-8] |
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