bio-THZ1 - ≥98% , CAS No.1604811-14-4

CAS: 1604811-14-4 Cat. No.: B647017 Molecular Weight: 1053.67 PubChem CID: 139035075

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7 . THZ1 is a selective and potent covalent CDK7 inhibitor with an IC 50 of 3.2 nM

Form:Solid

IC50& Target:CDK7

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7 . THZ1 is a selective and potent covalent CDK7 inhibitor with an IC 50 of 3.2 nM.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CN(CCCNC(=O)NCCOCCOCCOCCNC(=O)CCCCC1C2C(CS1)NC(=O)N2)CC=CC(=O)NC3=CC=C(C=C3)C(=O)NC4=CC=CC(=C4)NC5=NC=C(C(=N5)C6=CNC7=CC=CC=C76)Cl
• IUPAC Name: 4-[[(E)-4-[3-[2-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]propyl-methylamino]but-2-enoyl]amino]-N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide
• InChIKey: ARPCJVVFIKPHFA-SFDVBDGFSA-N
• INCHI: 1S/C52H65ClN12O8S/c1-65(24-8-20-55-51(69)56-22-26-72-28-30-73-29-27-71-25-21-54-45(66)14-5-4-13-44-48-43(34-74-44)62-52(70)64-48)23-7-15-46(67)59-36-18-16-35(17-19-36)49(68)60-37-9-6-10-38(31-37)61-50-58-33-41(53)47(63-50)40-32-57-42-12-3-2-11-39(40)42/h2-3,6-7,9-12,15-19,31-33,43-44,48,57H,4-5,8,13-14,20-30,34H2,1H3,(H,54,66)(H,59,67)(H,60,68)(H2,55,56,69)(H,58,61,63)(H2,62,64,70)/b15-7+/t43-,44-,48-/m0/s1
• PubChem CID: 139035075
• Molecular Weight: 1053.67

Chemical and Physical Properties

• Solubility: DMSO : 120 mg/mL (113.89 mM; Need ultrasonic)