Bisphenol A Diglycidyl Ether（BADGE） - Moligand™, ≥85% , CAS No.1675-54-3

CAS: 1675-54-3 Cat. No.: B131786 Summenformel: C₂₁H₂₄O₄ Molekulargewicht: 340.42 EG-Nummer: 216-823-5

QUALITÄT & REINHEIT Moligand™, ≥85%

Synonyms

BADGE|4,4'-Isopropylidenebis[1-(2,3-epoxypropoxy)benzene]|BISPHENOL A DIGLYCIDYL ETHER RESIN|2,2-bis(4-(2,3-epoxypropoxy)phenyl)propane|2,2-bis(4-(2,3-epoxypropoxy)phenyl)-propane|2,2-Bis(p-hydroxyphenyl)propane diglycidyl ether|4,3-epoxypropoxy)benzene]|2,2'-((1-Methylethylidene)bis(4,1-phenyleneoxymethylene))bisoxirane|Araldite GY 250|Bisphenol A-d6 Diglycidyl Ether|Propane, 2,2-bis (p-(2,3-epoxypropoxy)phenyl)|Diglycidyl ether of 4,4'-isopropylidenediphenol|2,2-bis-(4-Glycidyloxyphenyl)propane|2,2-Bis(4'-glycidyloxyphenyl)propane|2,2-Bis(4-glycidyloxyphenyl)propane|4,4'-Isopropylidenediphenol diglycidyl ether|2,2-Bis[p-(2,3-epoxypropoxy)phenyl]-Propane|Oxirane, 2,2'-((1-methylethylidene)bis(4,1-phenyleneoxymethylene))bis-|Propane, 2,2-bis(4-(2,3-epoxypropoxy)phenyl)-|4,4'-Bis(2,3-epoxypropoxy)diphenyldimethylmethane|Bis(4-hydroxyphenyl)dimethylmethane diglycidyl ether|2,2-Bis[p-(2,3-epoxypropoxy)phenyl]propane|NIOSH/SL1998000|2,2'-[propane-2,2-diylbis(4,1-phenyleneoxymethylene)]dioxirane|2,2-Bis[4-(2,3-epoxypropyloxy)phenyl]propane|Dian-bis-glycidylether [Czech]|2,2-Bis(4-hydroxyphenyl)propane, diglycidyl ether|BISPHENOL DIGLYCIDYL ETHER|2,2-Bis(phenyl-4-glycidoxy)propane|2,2-Bis[4-(2,3-epoxypropoxy)phenyl]propane|2,2-Bis[4-(2,3-epoxypropoxy)phenyl]-Propane|Oxirane, 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-|EP 274|Epotuf 37-140|Diglycidyl bisphenol A ether|Diglycidyl ether of bisphenol A|2,2-Bis(p-(2,3-epoxypropoxy)phenyl)propane|2,2-Bis(p-(2,3-epoxypropoxy)phenyl)-Propane|2-[[4-[2-[4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl]phenoxy]methyl]oxirane|Dian-bis-glycidylether|Diglycidyl bisphenol A|epi-Rez 510|Araldite F|Bisphenol A, diglycidyl ether|2, diglycidyl ether|4,4'-Dihydroxydiphenyldimethylmethane diglycidyl ether|2,2-Bis(p-hydroxyphenyl)propane, diglycidyl ether|2,3-epoxypropyloxy)phenyl]propane|Epoxide A|GY 6010|Propane, 2,2-bis[p-(2,3-epoxypropoxy)phenyl]-|DGEBA|2,2-Bis[4-(glycidyloxy)phenyl]propane|2,2-Bis(4-hydroxyphenyl)propane diglycidyl ether|2-((4-(2-(4-(oxiran-2-ylmethoxy)phenyl)propan-2-yl)phenoxy)methyl)oxirane|2,2-Bis(p-glycidyloxyphenyl)propane|4,4'-Isopropylidenebis(1-(2,3-epoxypropoxy)benzene)|Dian diglycidyl ether|Diglycidyl ether of 2,2-bis(p-hydroxyphenyl)propane|BISPHENOL A DIGLYCIDYL ETHER|ERL-2774|Epophen EL 5|isphenol a, diglycidyl ether|Diomethane diglycidyl ether|Epi-Rez 508|Propane, 2,2-bis(p-(2,3-epoxypropoxy)phenyl)-|2,2'-(PROPANE-2,2-DIYLBIS(4,1-PHENYLENEOXYMETHYLENE))DIOXIRANE|Diglycidyl diphenylolpropane ether|Diglycidyl ether of 2,2-bis(4-hydroxyphenyl)propane|bisphenol-a diglycidyl ether|Bisphenol-A diglycidylether|diglycidyl ether of bisphenol-A|p,p'-Dihydroxydiphenyldimethylmethane diglycidyl ether|BISPHENOLFDIGLYCIDYLETHER|Bpdge

Storage

Lagerung bei 2-8°C, Argon geladen

Shipped In

Nasses Eis

Übersicht

Bisphenol A Diglycidyl Ether ist ein Diglycidylether (BADGE), der den Peroxisom-Proliferator-aktivierten Rezeptor (PPARγ) und die Adipozytendifferenzierung hemmen kann und nachweislich die Apoptose in Tumorzellen auslöst. Die Forschung zeigt, dass BADGE den Tumor-Nekrose-Faktor-α (TNF-α) unterdrücken kann und die Fähigkeit besitzt, die Depolymerisation von F-Aktin zu induzieren.
Ein Inhibitor von PPARγ und Suppressor von TNF-α.

Spezifikationen

Synonyme

BADGE | 4,4'-Isopropylidenebis[1-(2,3-epoxypropoxy)benzene] | BISPHENOL A DIGLYCIDYL ETHER RESIN | 2,2-bis(4-(2,3-epoxypropoxy)phenyl)propane | 2,2-bis(4-(2,3-epoxypropoxy)phenyl)-propane | 2,2-Bis(p-hydroxyphenyl)propane diglycidyl ether | 4,3-epoxypropoxy)benzene] | 2,2'-((1-Methylethylidene)bis(4,1-phenyleneoxymethylene))bisoxirane | A Show more

Spezifikationen & Reinheit

Moligand™, ≥85%

Biochemische und physiologische Mechanismen

Selektiver PPARγ-Antagonist. Löst PPARγ-unabhängige Apoptose von Tumorzellen aus. Steigert die Osteoblastogenese und die Knochenmasse in vivo.

Storage

Lagerung bei 2-8°C, Argon geladen

Verschickt in

Nasses Eis

Note

Moligand™

Hinweis

Wenn möglich, sollten Sie die Lösungen noch am selben Tag zubereiten und verwenden. Wenn Sie jedoch Stammlösungen im Voraus herstellen müssen, empfehlen wir Ihnen, die Lösung als Aliquote in dicht verschlossenen Fläschchen bei -20 °C zu lagern. Diese sind in der Regel bis zu einem Monat haltbar. Vor der Verwendung und vor dem Öffnen des Fläschchens empfehlen wir, das Produkt mindestens 1 Stunde lang auf Raumtemperatur kommen zu lassen. Benötigen Sie weitere Ratschläge zur Löslichkeit, Verwendung und Handhabung? Besuchen Sie unsere Seite mit den häufig gestellten Fragen (FAQ) für weitere Informationen.

Reinheit

≥85%

Namen und Kennungen

Pubchem Sid

508812754

Kanonisches Lächeln

CC(C)(C1=CC=C(C=C1)OCC2CO2)C3=CC=C(C=C3)OCC4CO4

IUPAC Name

2-[[4-[2-[4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl]phenoxy]methyl]oxirane

InChIKey

LCFVJGUPQDGYKZ-UHFFFAOYSA-N

INCHI

1S/C21H24O4/c1-21(2,15-3-7-17(8-4-15)22-11-19-13-24-19)16-5-9-18(10-6-16)23-12-20-14-25-20/h3-10,19-20H,11-14H2,1-2H3

Isomere SMILES

CC(C)(C1=CC=C(C=C1)OCC2CO2)C3=CC=C(C=C3)OCC4CO4

RTECS

TX3800000

Molekulargewicht

340.42

Reaxy-Rn

299026

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=299026&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Benzene and substituted derivatives
      • Subclass Diphenylmethanes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Benzene and substituted derivatives
• Subclass: Diphenylmethanes
• Intermediate Tree Nodes: Not available
• Direct Parent: Diphenylmethanes
• Alternative Parents: Phenylpropanes Phenoxy compounds Phenol ethers Alkyl aryl ethers Oxacyclic compounds Epoxides Dialkyl ethers Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Diphenylmethane - Phenylpropane - Phenoxy compound - Phenol ether - Alkyl aryl ether - Oxacycle - Organoheterocyclic compound - Ether - Oxirane - Dialkyl ether - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
• External Descriptors: diarylmethane

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

Discover Target: ESR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR3C1 Tclin Glucocorticoid receptor (14987 Activities)

Discover Target: NR3C1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VDR Tclin Vitamin D receptor (26531 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

Discover Target: TSHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

Discover Target: PPARG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RXRA Tclin Retinoid X receptor alpha (3637 Activities)

Discover Target: RXRA

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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

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NR1H4 Tclin Bile acid receptor FXR (6228 Activities)

Discover Target: NR1H4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

Discover Target: TP53

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Lymphoblastoid cell (5959 Activities)

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HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)

Discover Target: HIF1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)

Discover Target: HPGD

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Zugehörige Ziele (nicht menschlich)

Ppard Peroxisome proliferator-activated receptor delta (358 Activities)

Discover Target: Ppard

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H4 (48 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

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Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

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FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in 100% ethanol, DMSO (100 mM), DMF, chloroform, methanol, and ethanol (50 mM). Insoluble in PBS, pH 7.2, and water.
• Empfindlichkeit: Heat & Moisture Sensitive.
• Brechungsindex: 1.57
• Siedepunkt (°C): 210 °C/1 mmHg
• Molekulargewicht: 340.400 g/mol
• XLogP3: 4.000
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 340.167 Da
• Monoisotopic Mass: 340.167 Da
• Topological Polar Surface Area: 43.500 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 384.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 2
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1