BJE6-106 - ≥99% , CAS No.1564249-38-2

CAS: 1564249-38-2 Cat. No.: B646794 Summenformel: C₂₆H₂₃NO₂ Molekulargewicht: 381.47 PubChem CID: 85471521

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

BJE6-106 (B106) is a potent, selective 3 rd generation PKCδ inhibitor with an IC 50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC 50 =50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis . BJE6-106 (B106) possesses tumor-specific effect.

In Vitro

BJE6-106 (B106) (0.2 μM, 0.5 μM; 24-72 hours) suppresses cell survival in melanoma cell lines with NRAS mutations. BJE6-106 (B106) (0.2 μM, 0.5 μM; 6-24 hours) triggers caspase-dependent apoptosis, increases the activity of caspase 3/7, the effect of B106 is greater than rottlerin (10-fold) in SBcl2 cells. BJE6-106 (B106) (0.5 μM; 2-10 hours) activates the MKK4-JNK-H2AX Pathway by inducing MKK4, JNK and H2AX activation at different times in SBcl2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Melanoma cell lines with NRAS mutations: SBcl2, FM6, SKMEL2, WM1366, WM1361A, and WM852 cells Concentration: 0.2 μM, 0.5 μM Incubation Time: 24 hours, 48 hours, or 72 hours Result: Inhibited cell survival in melanoma cell lines. Apoptosis AnalysisCell Line: SBcl2 cells Concentration: 0.2 μM, 0.5 μM Incubation Time: 6 hours, 12 hours, or 24 hours Result: Induced caspase 3/7 activation. Western Blot AnalysisCell Line: SBcl2 cells Concentration: 0.2 μM, 0.5 μM Incubation Time: 2 hours, 5 hours, 10 hours Result: Increased phosphorylation of MKK4, JNK and H2AX.

Form:Solid

IC50& Target:PKCδ 0.05 μM (IC 50 ) PKCα 50 μM (IC 50 )

Specifications

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

BJE6-106 (B106) is a potent, selective 3 rd generation PKCδ inhibitor with an IC 50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC 50 =50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis . BJE6-106 (B106) possesses tumor-s

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

ACTIVATOR

Reinheit

≥99%

Namen und Kennungen

• Kanonisches Lächeln: CC1(C=CC2=C(O1)C(=CC(=C2)CCN3C4=CC=CC=C4C5=CC=CC=C53)C=O)C
• IUPAC Name: 6-(2-carbazol-9-ylethyl)-2,2-dimethylchromene-8-carbaldehyde
• InChIKey: QLDDENZBVHBRKN-UHFFFAOYSA-N
• INCHI: 1S/C26H23NO2/c1-26(2)13-11-19-15-18(16-20(17-28)25(19)29-26)12-14-27-23-9-5-3-7-21(23)22-8-4-6-10-24(22)27/h3-11,13,15-17H,12,14H2,1-2H3
• Isomere SMILES: CC1(C=CC2=C(O1)C(=CC(=C2)CCN3C4=CC=CC=C4C5=CC=CC=C53)C=O)C
• PubChem CID: 85471521
• MeSH-Eintrag: 6-(2-(9h-Carbazol-9-yl)ethyl)-2,2-dimethyl-2h-chromene-8-carbaldehyde;BJE6-106;PKCdelta Inhibitor B106
• Molekulargewicht: 381.47

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Indoles and derivatives
      • Subclass Carbazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Indoles and derivatives
• Subclass: Carbazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Carbazoles
• Alternative Parents: 2,2-dimethyl-1-benzopyrans N-alkylindoles Aryl-aldehydes Alkyl aryl ethers Substituted pyrroles Benzenoids Heteroaromatic compounds Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Carbazole - 2,2-dimethyl-1-benzopyran - N-alkylindole - 1-benzopyran - Benzopyran - Aryl-aldehyde - Alkyl aryl ether - Benzenoid - Substituted pyrrole - Heteroaromatic compound - Oxacycle - Azacycle - Ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aldehyde - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as carbazoles. These are compounds containing a three ring system containing a pyrrole ring fused on either side to a benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 50 mg/mL (131.07 mM; Need ultrasonic)