Bocidelpar - Moligand™,≥98% , CAS No.2095128-20-2

CAS: 2095128-20-2 Cat. No.: B648929 Summenformel: C₂₅H₂₇F₃N₂O₃ Molekulargewicht: 460.49 PubChem CID: 126752383

GRADE & PURITY Moligand™, ≥98%

Synonyms

(R)-3-Methyl-6-(2-((5-methyl-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid | ASP0367 | MA-0211 | SP-0367

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Bocidelpar is a selective PPARδ modulator. Bocidelpar activates the PPARδ downstream signaling pathway, upregulates the expression of target genes such as ABCA1 and ACAA2. Bocidelpar then promotes fatty acid oxidation (FAO) and mitochondrial biogenesis, and improves mitochondrial dysfunction. Bocidelpar can improve mitochondrial biogenesis and function in muscle cells. Bocidelpar is mainly used in the study of mitochondrial dysfunction diseases such as primary mitochondrial myopathy (PMM) and Duchenne muscular dystrophy (DMD).

Specifications

Synonyme

(R)-3-Methyl-6-(2-((5-methyl-2-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid | ASP0367 | MA-0211 | SP-0367

Spezifikationen & Reinheit

Moligand™,≥98%

Biochemische und physiologische Mechanismen

Bocidelpar is a modulator of peroxisome proliferator-activated receptor delta ( PPAR-δ ). Bocidelpar improves mitochondrial biogenesis and function in Duchenne Muscular Dystrophy (DMD) muscle cells (extracted from patent WO2017062468A1, compound 2b).

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

MODULATOR

Reinheit

≥98%

Namen und Kennungen

• Isomere SMILES: CC1=CN=C(N1CC2=CC=CC=C2OCCC[C@@H](C)CC(=O)O)C3=CC=C(C=C3)C(F)(F)F
• PubChem CID: 126752383
• Molekulargewicht: 460.49

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 250 mg/mL (542.90 mM; Need ultrasonic)
• Molekulargewicht: 460.500 g/mol
• XLogP3: 5.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 460.197 Da
• Monoisotopic Mass: 460.197 Da
• Topological Polar Surface Area: 64.400 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 610.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1