Broflanilide - ≥99% , CAS No.1207727-04-5

CAS: 1207727-04-5 Cat. No.: B647090 Summenformel: C₂₅H₁₄BrF₁₁N₂O₂ Molekulargewicht: 663.28 EG-Nummer: 690-677-4 PubChem CID: 53341374

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Broflanilide is a potential insecticide and metabolized to Desmethyl-Broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA Receptor , and inhibits S. litura RDL GABAR, with an IC 50 value of 1.3 nM.

In Vitro

Broflanilide is an insecticide and metabolized to desmethyl-broflanilide, which is a potent and selective antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC 50 value of 1.3 nM. Desmethyl-broflanilide shows weak activity against human GABA A α1β2γ2 receptor, the mammalian GABA A α1β3γ2 receptor and human glycine receptor (GlyR) α1β with IC 50 s of >3 μM, and less potently inhibits GlyR α1-A288Gβ and GlyR α1-A288G (IC 50 s, 0.706, 0.149 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

Broflanilide is a potential insecticide and metabolized to Desmethyl-Broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA Receptor , and inhibits S. litura RDL GABAR, with an IC 50 value of 1.3 nM.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

ANTAGONIST

Reinheit

≥99%

Namen und Kennungen

• Isomere SMILES: CN(C1=CC=CC(=C1F)C(=O)NC2=C(C=C(C=C2Br)C(C(F)(F)F)(C(F)(F)F)F)C(F)(F)F)C(=O)C3=CC=CC=C3
• PubChem CID: 53341374
• Molekulargewicht: 663.28

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 250 mg/mL (376.91 mM; Need ultrasonic)
• Molekulargewicht: 663.300 g/mol
• XLogP3: 7.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 5
• Exact Mass: 662.006 Da
• Monoisotopic Mass: 662.006 Da
• Topological Polar Surface Area: 49.400 Ų
• Heavy Atom Count: 41
• Formal Charge: 0
• Complexity: 922.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referenzen

1. Yifan Li, Shujun Ni, Yunping Wang, Ruichi Li, Hong Sun, Xuan Ye, Zhen Tian, Yalin Zhang, Jiyuan Liu.  (2023)  The chemosensory protein 1 contributes to indoxacarb resistance in Plutella xylostella (L.).  PEST MANAGEMENT SCIENCE,      [PMID:36809665] [10.1002/ps.7415]