≥95%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Protected from light,Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
product description：
Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent[1]. Brusatol increases cellular apoptosis。
This compound belongs to the class of organic compounds known as quassinoids. These are a group of compounds chemically degraded from triterpenes. According to their basic skeleton, quassinoids are categorized into five distinct groups, C-18, C-19, C-20, C-22 and C-25 types. The C-20 quassinoids can be further classified into two types, tetracyclic and the pentacyclic. The tetracyclic variety does not have oxygenation at C-20, while the pentacyclic quassinoids possess additional oxygenation at C-20 that allows for the formation of an additional ring.
External Descriptors
Dammarenes
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Wang Zhi-shun, Shu Bo, Han Qi, Li Guo-hao, Guo Yong-lian. (2023) Effects of grape seed-derived proanthocyanidin B2 pretreatment on oxidative stress, endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells in renal ischemia–reperfusion injury model of mice. INTERNATIONAL UROLOGY AND NEPHROLOGY, [PMID:36935438][10.1007/s11255-023-03494-4]
2.Na Wei, Tan Lu, Libin Yang, Yonghan Dong, Xiaotan Liu. (2021) Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway. FEBS Open Bio, 11 (8):(2118-2126). [PMID:34048148][10.1002/2211-5463.13203]
3.Mengmeng Zhang, Tianchui Wang, Sixian Ou, Yucong Zou, Xuan Xin. (2024) Betaine activates the Nrf2-Keap1-ARE pathway by increasing the methylation level of Keap1 DNA promoter. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 59 (9):(6231-6242). [PMID:][10.1111/ijfs.17359]
4.Zhi-shun Wang, Qi Han, Hao Shen, Bo Shu, Cheng-cheng Ying, Guo-hao Li, Yong-lian Guo. (2025) Impact of grape seed proanthocyanidin B2 pretreatment on mitochondrial oxidative stress, endoplasmic reticulum stress, and apoptosis in renal tubular epithelial cells during in-vitro hypoxia-reoxygenation. Acta Cirurgica Brasileira, [PMID:40498953][10.1590/acb404125]
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