Butyzamide - ≥99% , CAS No.1110767-45-7

CAS: 1110767-45-7 Cat. No.: B648013 Summenformel: C₂₉H₃₂Cl₂N₂O₅S Molekulargewicht: 591.55

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Übersicht

Butyzamide is an orally active activator of Mpl , a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2 , STAT3 , STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay

In Vitro

Butyzamide (3 μM; 15 min) induces the phosphorylation of JAK2, STAT3, STAT5 and MAPK in Ba/F3-hMpl cells. Butyzamide (3 μM; 48 h) induces colony-forming unit-megakaryocyte and polyploid meggakaryocytes from human CD34 + hematopoietic progenitor cellls. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Butyzamide (10 mg/kg, 50 mg/kg; p.o.; once daily for 20 days) increases human platelets in NOG mice transplanted with human fetal liver-derived CD34 + cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:JAK2 STAT3 STAT5

Specifications

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

Butyzamide is an orally active activator of Mpl , a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2 , STAT3 , STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay.

Storage

Store at 2-8°C,Protected from light,Desiccated

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

ACTIVATOR

Reinheit

≥99%

Namen und Kennungen

• Molekulargewicht: 591.55

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 100 mg/mL (169.05 mM; Need ultrasonic)