Calmodulin from bovine testes - ≥98%(SDS-PAGE) , CAS No.77107-46-1

CAS: 77107-46-1 Cat. No.: C140110

GRADE & PURITY ≥98%(SDS-PAGE)

Synonyms

CaM, Phosphodiesterase 3′:5′-cyclic nucleotide activator

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Calmodulin is a bioactive protein isolated from bovine testes with a molecular weight of 16,7 kDa. The material is derived from cattle born and raised in Sweden, a country where BSE is non-existing. Calmodulin is a calcium-binding protein expressed in many eukaryotic cells. By binding to and regulating various protein targets, it affects cellular processes such as metabolism, nerve growth, apoptosis, inflammation, muscle contraction and memory. Many proteins use Calmodulin as a calcium sensor and signal transducer, as the proteins themselves are not able to bind calcium. The molecule can bind a maximum of four calcium ions and by undergoing post-translational modifications such as acetylation, phosphorylation, proteolytic cleavage and methylation, its functions can potentially be altered. Calmodulin is supplied as a lyophilized white powder or flocculate from 50 mM NH4HCO3 with 10 μM CaCl2. No preservatives are added. The protein content is analyzed by amino acid assay and is never less than 80 % of weighed substance. The material has been subjected to an acid treatment for minimum 30 min. The protein is derived from a single batch and is homogenous.
Protein calcium binding studies on the regulation of a multitude of different protein targets; Activation of cyclic nucleotide-dependent phosphodiesterase; Co-factor/activator for kinase studies; Studies of edema factor toxin and anthrax bacteria

Specifications

Synonyms

CaM, Phosphodiesterase 3′:5′-cyclic nucleotide activator

Specifications & Purity

≥98%(SDS-PAGE)

Biochemical and Physiological Mechanisms

Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, I

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%(SDS-PAGE)