Capzimin - 10mM in DMSO , CAS No.2084868-04-0

CAS: 2084868-04-0 Cat. No.: C656015 Summenformel: C₃₀H₂₄N₆O₂S₄ Molekulargewicht: 628.81 PubChem CID: 126599606

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Capzimin is a potent and moderately specific proteasome isopeptidase Rpn11 inhibitor.

In Vitro

Capzimin (3027) shows 80-fold selectivity for Rpn11 over Csn5, 10-fold over AMSH and 6-fold over BRCC36 (IC 50 =30 μM, 4.5 μM and 2.3 μM respectively. Capzimin is screened against the NCI panel of 60 cancer cell lines. The median GI 50 is 3.3 μM. Capzimin exhibits promising activity in leukemia cells including the SR and K562 cell lines (GI 50 values of 0.67 μM and 1 μM respectively), as well as several solid tumor cell lines including NCI-H460 (non-small cell lung cancer; GI 50 = 0.7 μM) and MCF7 (breast cancer; GI 50 =1.0 μM). Immunoblotting for the processed form of caspase 3 and caspase-cleaved poly ADP-ribose polymerase in HCT116 cells confirm that Capzimin not only blocks cell growth, but also induces apoptosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Target: Rpn11

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Capzimin is a potent and moderately specific proteasome isopeptidase Rpn11 inhibitor.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Namen und Kennungen

• Isomere SMILES: C1=CC2=CC(=CN=C2C(=C1)SSC3=CC=CC4=CC(=CN=C43)C(=O)NCCC5=NC=CS5)C(=O)NCCC6=NC=CS6
• PubChem CID: 126599606
• Molekulargewicht: 628.81

Zugehörige Ziele (menschlich)

PSMD14 Tchem 26S proteasome non-ATPase regulatory subunit 14 (2 Activities)

Discover Target: PSMD14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)