Carbenicillin disodium - 10mM in DMSO , Bacterial penicillin-binding protein inhibitor, CAS No.4800-94-6, Bacterial penicillin-binding protein inhibitor

CAS: 4800-94-6 Cat. No.: C408933 Molecular Weight: 422.36 Beilstein Registry Number: 5722128 EC Number: 225-360-8

GRADE & PURITY 10mM in DMSO

Synonyms

BRL-2064 | 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(2-carboxy-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-, sodium salt (1:2), (2S,5R,6R)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Carbenicillin (BRL-2064) is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity.
In vitro

Carbenicillin (125 mg/L) completely suppresses the proliferation of Agrobacterium. Carbenicillin (250 mg/L-500 mg/L) enhances Callus fresh weight increase. Carbenicillin (125 mg/L) results in higher percentages of somatic embryos and larger numbers of somatic embryos from the individual callus. Carbenicillin (1g/L) influences shoot formation negatively as the shooting frequency for leaf disc explants is reduced to 56% and for cotyledons to 51% after 2 months of culture of Nicotiana tabacum Petit Havana. Carbenicillin prevents the development of mature somatic embryos, reduces early stage embryos by >90% and tissue growth by 50% of Sitka spruce. The leukocytes of the patients does not release histamine on in vitro provocation with Carbenicillin (0.1 g/mL).

In vivo

Carbenicillin (0.1 g/mL) does not show any allergic drug reactions in cystic fibrosis patients, as evident by no significant levels of antibodies of IgE, IgG or IgM classes. Carbenicillin (50 μg/mL) results in phytotoxicity in chrysanthemum and TOB, with an increase in the concentration, and with a parallel shift in the morphogenic capacity (SRC) of threshold survival levels (TSLs). Carbenicillin results in 100% acclimatization with no different morphological flowering characteristics following subculture in vitro three times in Chrysanthemum plantlets.
Cell Data

cell lines：

Concentrations：

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Specifications

Synonyms

BRL-2064 | 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(2-carboxy-2-phenylacetyl)amino]-3, 3-dimethyl-7-oxo-, sodium salt (1:2), (2S, 5R, 6R)-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Carbenicillin (BRL-2064) is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Bacterial penicillin-binding protein inhibitor

Names and Identifiers

• Isomeric SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)C(C3=CC=CC=C3)C(=O)[O-])C(=O)[O-])C.[Na+].[Na+]
• WGK Germany: 2
• RTECS: ON9105000
• Alternate CAS: 4697-36-3（free basis）
• Molecular Weight: 422.36
• Beilstein: 5722128
• Reaxy-Rn: 52589494
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=52589494&ln=

Chemical and Physical Properties

• Flash Point(°F): 752℉
• Flash Point(°C): 400℃
• Boil Point(°C): 738℃
• Melt Point(°C): >200℃

References

1. Shuai Han, Liang Yang, Zhigang Wen, Suyun Chu, Mei Wang, Zhenyang Wang, Changlong Jiang.  (2020)  A dual-response ratiometric fluorescent sensor by europium-doped CdTe quantum dots for visual and colorimetric detection of tetracycline.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:32768819] [10.1016/j.jhazmat.2020.122894]

2. Xin Jiang, Yongliang Chen, Juan Du, Ming Yang, Yu Shen, Xiuling Li, Xiaoxia Han, Libin Yang, Bing Zhao.  (2018)  SERS investigation and high sensitive detection of carbenicillin disodium drug on the Ag substrate.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:29936221] [10.1016/j.saa.2018.06.059]