Carbimazole - 10mM in DMSO , Thyroid peroxidase inhibitor, CAS No.22232-54-8, Thyroid peroxidase inhibitor

CAS: 22232-54-8 Cat. No.: C408083 Molecular Weight: 186.23 EC Number: 244-854-4

GRADE & PURITY 10mM in DMSO

Synonyms

1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Carbimazole is an imidazole antithyroid agent.
In vitro

Carbimazole is an effective thyroid hormone inhibitor under a class of drugs known as pro-drugs. It is considered a pro-drug because it converts to methimazole after being absorbed by the body, generating an antithyroid action that works against hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (inflammation of the thyroid gland). Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine).

In vivo

Cell Data

cell lines：Human breast cancer cells MDA-MB-231

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

1H-Imidazole-1-carboxylic acid, 2, 3-dihydro-3-methyl-2-thioxo-, ethyl ester

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Carbimazole is an imidazole antithyroid agent.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Thyroid peroxidase inhibitor

Product Properties

• ALogP: 0.7

Names and Identifiers

• Isomeric SMILES: CCOC(=O)N1C=CN(C1=S)C
• WGK Germany: 3
• Molecular Weight: 186.23
• Reaxy-Rn: 144339
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=144339&ln=

Chemical and Physical Properties

• Melt Point(°C): 124 °C

References

1. Nian Liu, Shuchao Zhang, Yiliang Liu, Xing Lu, Xiaozhen He.  (2025)  Potential Mechanisms Underlying Carbimazole-Induced Cardiotoxicity and Hepatotoxicity in Zebrafish.  JOURNAL OF APPLIED TOXICOLOGY,      [PMID:40784728] [10.1002/jat.4889]