Carbimazole - 10mM in DMSO , Thyroid peroxidase inhibitor, CAS No.22232-54-8, Thyroid peroxidase inhibitor

CAS: 22232-54-8 Cat. No.: C408083 Summenformel: C₇H₁₀N₂O₂S Molekulargewicht: 186.23 EG-Nummer: 244-854-4

GRADE & PURITY 10mM in DMSO

Synonyms

1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Carbimazole is an imidazole antithyroid agent.
In vitro

Carbimazole is an effective thyroid hormone inhibitor under a class of drugs known as pro-drugs. It is considered a pro-drug because it converts to methimazole after being absorbed by the body, generating an antithyroid action that works against hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (inflammation of the thyroid gland). Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine).

In vivo

Cell Data

cell lines：Human breast cancer cells MDA-MB-231

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyme

1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Carbimazole is an imidazole antithyroid agent.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Thyroid peroxidase inhibitor

Produkteigenschaften

• ALogP: 0.7

Namen und Kennungen

• Isomere SMILES: CCOC(=O)N1C=CN(C1=S)C
• WGK Deutschland: 3
• Molekulargewicht: 186.23
• Reaxy-Rn: 144339
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=144339&ln=

Chemische und physikalische Eigenschaften

• Schmelzpunkt (°C): 124 °C

Referenzen

1. Nian Liu, Shuchao Zhang, Yiliang Liu, Xing Lu, Xiaozhen He.  (2025)  Potential Mechanisms Underlying Carbimazole-Induced Cardiotoxicity and Hepatotoxicity in Zebrafish.  JOURNAL OF APPLIED TOXICOLOGY,      [PMID:40784728] [10.1002/jat.4889]