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CCG273441 - ≥98% , CAS No.2750414-35-6
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
CCG273441 is a covalent inhibitor of G protein-coupled receptor ( GPCR ) kinase 5 ( GRK5 ) with an IC 50 value of 3.8 nM. CCG273441 is highly selective to GRK5 over GRK2 (IC 50 =4.8 μM) by binding Cys474, a GRK5 subfamily-specific residue, as a covalent handle
In Vitro
Human GRKs (GRK1−GRK7) are classified into three subfamilies: GRK1 (GRK1 and GRK7), GRK2 (GRK2 and GRK3), and GRK4 (GRK4, GRK5, and GRK6). CCG273441 (compound 9j) shows moderate potency (GRK5 IC 50 =3.8 nM) but 1000-fold selectivity over GRK2 (IC 50 =4.8 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:IC50: 3.8 nM (human GRK5), 19 nM (GRK5-C474S), 4.8 μM (bovine GRK2)
Specifications
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
CCG273441 is a covalent inhibitor of G protein-coupled receptor ( GPCR ) kinase 5 ( GRK5 ) with an IC 50 value of 3.8 nM. CCG273441 is highly selective to GRK5 over GRK2 (IC 50 =4.8 μM) by binding Cys474, a GRK5 subfamily-specific residue, as a covalent h
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥98%
Names and Identifiers
| Molecular Weight | 494.95 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 50 mg/mL (101.02 mM; Need ultrasonic) |
|---|
Solution Calculators
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Customer Reviews
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