CCT129957 - Moligand™, 10mM in DMSO , Inhibitor of PLCγ2, CAS No.883098-58-6, Inhibitor of PLCγ2

CAS: 883098-58-6 Cat. No.: C656824 Summenformel: C₁₇H₁₅N₃O₃ Molekulargewicht: 309.32

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC 50 of ~3 μM and a GC 50 of 15 μM. CCT129957 inhibits Ca 2+ release in squamous carcinoma cells at ~15 μM

In Vitro

The phenyl group on the left side sat in a lipophilic pocket formed of various amino acids. The predicted binding mode of CCT129957 displays a robust hydrogen bond pattern as well as a lipophilic contact. CCT129957 inhibits the cell growth of renal UO-31 and the breast T-47D cancer cell lines by ~60-70%. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: ~3 μM (Phospholipase C-γ (PLC-γ))

Specifications

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC 50 of ~3 μM and a GC 50 of 15 μM. CCT129957 inhibits Ca 2+ release in squamous carcinoma cells at ~15 μM.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Inhibitor of PLCγ2

Namen und Kennungen

• Molekulargewicht: 309.32

Zugehörige Ziele (menschlich)

PLCG2 Tchem 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (2 Activities)

Discover Target: PLCG2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)