CD155/PVR Rat mAb - Primärer Antikörper, specific to CD155/PVR, Rat IgG2a

Cat. No.: Ab122568

GRADE & PURITY Carrier Free, Validated, ExactAb™, Low Endotoxin, Azide Free, PBS Only, ≥95%(SDS-PAGE&HPLC), See COA

Application

Flow Cytometry, Functional Assay, WB

Host species

Rat

Reactive species

Maus

Isotype

Rat IgG2a

Clone Number

4.24

Conjugation

Unconjugated

Übersicht

Rat anti Mouse CD155/PVR Antibody, Monoclonal (4.24), could be used for WB, Functional Assays, Flow and so on.
Application

WB: Use at an assay dependent concentration.

Functional Assays: Use at an assay dependent concentration.

Flow: Use at an assay dependent concentration.
Protein Function
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.

Specifications

Product Name

CD155/PVR Rat mAb - Primärer Antikörper, specific to CD155/PVR, Rat IgG2a

Synonyme

mE4 | Taa1 | necl-5 | D7Ertd458e | 3830421F03Rik | CD155 antigen | CD155 | HVED | NECL5 | nectin-like 5 | Nectin-like protein 5 | poliovirus receptor | PVR | PVS | PVSFLJ25946 | Tage4 | CD155 antibody | CD155 antigen antibody | FLJ25946 antibody | HVED an

Spezifikationen & Reinheit

Carrier Free,ExactAb™,Low Endotoxin,Azide Free,Validated,PBS Only,≥95%(SDS-PAGE&HPLC),See COA

Wirtsspezies

Rat

Spezifität

CD155/PVR

Konjugation

Unconjugated

Note

Azide Free, Carrier Free, ExactAb™, Low Endotoxin, PBS Only, Validated

Isotyp

Rat IgG2a

Lichterketten-Typ

kappa

SDS-PAGE

150 kDa

Verfahren zur Reinigung

Protein G purified

Konzentration

See COA

Lagerung und Versand

Form

Liquid

Storage

Store at -20°C,Avoid repeated freezing and thawing

Verschickt in

Ice chest + Ice pads

Stabilität und Lagerung

Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Bilder

Flow Cytometry: CD155/PVR Rat mAb (Ab122568)

CD155/PVR Rat mAb (Ab122568) - Flow Cytometry
Flow Cytometry analysis of thymocytes cells labelling CD155/PVR (red) with CD155/PVR Rat mAb (Ab122568) conjugated with biotin at 0.5 μg/mL for 1 hour at 4°C, and detected with SA-PE (rp156150). Blue - Rat IgG Isotype Control Antibody (Biotin) (Ab180310). Black - Unlabelled control, cells without incubation with primary antibody.

Anwendung

• Anwendung: Dilution info
• WB:

  Use at an assay dependent concentration.;

• Functional Assay:

  Use at an assay dependent concentration.;

• Flow Cytometry:

  Use at an assay dependent concentration.

Häufig gestellte Fragen

What does ExactAb? mean?

ExactAb? indicates the product has been validated for use in rigorous antibody validation workflows. Validation may include positive/negative control samples, signal-to-noise testing, and protocol-specific QC. Lot-specific test data is published on the Certificate of Analysis where available.

What does Carrier Free mean?

Carrier Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

How should this product be stored?

Store at ?20 °C. Avoid repeated freeze–thaw cycles. Aliquot into single-use volumes before freezing.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

Which species reactivity has this antibody been validated against?

Validated reactivity is listed on the PDP and on each lot's datasheet. We validate against the most commonly tested species for the target (CD155/PVR Rat mAb); cross-reactivity in untested species may exist but is not guaranteed. Contact technical support for specific species inquiries.