CDK9-IN-7 - 10mM in DMSO , CAS No.2369981-71-3

CAS: 2369981-71-3 Cat. No.: C656458 Summenformel: C₂₉H₃₇N₇O₂S Molekulargewicht: 547.71 PubChem CID: 138911336

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

CDK9-IN-7 (compound 21e) is a selective, highly potent, and orally active CDK9/cyclin T inhibitor ( IC 50 =11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM). CDK9-IN-7 shows antitumor activity without obvious toxicity. CDK9-IN-7 induces NSCLC cell apoptosis , arrests the cell cycle in the G2 phase, and suppresses the stemness properties of NSCLC

In Vitro

CDK9-IN-7 displays exceptional potency against NSCLC cell lines, especial A549 and H1299 with IC 50 values less than 0.5 µM. In the drug-resistant NSCLC cell line H1975, CDK9-IN-7 also exhibits good inhibition potency with an IC 50 value of 0.837 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:CDK9/cyclinT1 11 nM (IC 50 ) CDK4/cyclin D 148 nM (IC 50 ) CDK6/cyclinD 145 nM (IC 50 )

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

CDK9-IN-7 (compound 21e) is a selective, highly potent, and orally active CDK9/cyclin T inhibitor ( IC 50 =11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM). CDK9-IN-7 shows antitumor activity without obvious to

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Isomere SMILES

CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(C=C4)NC(=O)CCCCCCCN=C=S

PubChem CID

138911336

Molekulargewicht

547.71