CHIKV-IN-2 - ≥98% , CAS No.2361289-44-1

CAS: 2361289-44-1 Cat. No.: C650428 Summenformel: C₂₃H₂₆N₂O₂ Molekulargewicht: 362.46 PubChem CID: 142616713

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV) , with excellent cellular antiviral activity ( EC 90 =270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH) , which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools

In Vitro

CHIKV-IN-2 (compound 8q) is a potent pan-alphavirus inhibitor, with EC 90 s of 0.85-2.5 μM for CHIKV clinical isolates and attenuated vaccine strains. CHIKV-IN-2 is active against alphavirus VEEV (EC 90 =0.40 μM) as well as flaviviruses such as West Nile Virus (WNV, EC 90 =0.20 μM) and Dengue Virus Strain-2 (DENV-2, EC 90 =0.60 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CHIKV-IN-2 (compound 8q) (80 mg/kg; i.p. twice a day for 3 days) significantly decreases infectious CHIKV dissemination to other tissues of mice . CHIKV-IN-2 (40 mg/kg; p.o., i.p., s.c.) exhibits moderate bioavailability (F=41%, 43%, 4%), terminal elimination half-life (t 1/2 =9.9, 18.5, 18.6 h) and C max (642, 858, 90 ng/mL) in mice . CHIKV-IN-2 (1 mg/kg; i.v.) exhibits terminal elimination half-life (t 1/2 = 2.02 h) and AUC (497 h•ng/mL) in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female and male C57BL/6 mice Dosage: 80 mg/kg Administration: I.p. twice a day for 3 days Result: Failed to inhibit virus loads at the site of infection. Decreased virus dissemination to other tissues. Animal Model: Male C57BL/6 mice were challenged with CHIKV in the right footpad Dosage: 1 mg/kg for i.v. and 40 mg/kg for p.o., i.p., s.c. (Pharmacokinetic Analysis) Administration: I.v., p.o., i.p., s.c. Result: I.v.: t 1/2 = 2.02 h; AUC=497 h•ng/mL. P.o.: F=41%; t 1/2 =9.9 h; C max =642 ng/mL. I.p.: F=43%; t 1/2 =18.5 h; C max =858 ng/mL. S.c.: F=4%; t 1/2 =18.6 h; C max =90 ng/mL.

Form:Solid

IC50& Target:EC90: 270 nM (Chikungunya virus), Dihydroorotate Dehydrogenase

Specifications

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV) , with excellent cellular antiviral activity ( EC 90 =270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydro

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥98%

Namen und Kennungen

• Kanonisches Lächeln: CC(C)(C#N)C1=CC=C(C=C1)NC(=O)C2=C(C=C3CCCCCC3=C2)OC
• IUPAC Name: N-[4-(2-cyanopropan-2-yl)phenyl]-3-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-carboxamide
• InChIKey: WAOHPFHXTKBTTG-UHFFFAOYSA-N
• INCHI: 1S/C23H26N2O2/c1-23(2,15-24)18-9-11-19(12-10-18)25-22(26)20-13-16-7-5-4-6-8-17(16)14-21(20)27-3/h9-14H,4-8H2,1-3H3,(H,25,26)
• Isomere SMILES: CC(C)(C#N)C1=CC=C(C=C1)NC(=O)C2=C(C=C3CCCCCC3=C2)OC
• PubChem CID: 142616713
• Molekulargewicht: 362.46

Zugehörige Ziele (menschlich)

DHODH Tclin Dihydroorotate dehydrogenase (2737 Activities)

Discover Target: DHODH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NHDF (1164 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK293 (82097 Activities)

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Zugehörige Ziele (nicht menschlich)

Venezuelan equine encephalitis virus (381 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

West Nile virus (623 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

dengue virus type 2 (2400 Activities)

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Mayaro virus (6 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Chikungunya virus (1339 Activities)

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Onyong-nyong virus (4 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 100 mg/mL (275.89 mM; Need ultrasonic)

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2361289-44-1, the molecular formula is C23H26N2O2, and the molecular weight is 362.46 g/mol. InChIKey WAOHPFHXTKBTTG-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.