Chroman 1 - ≥98% , CAS No.1273579-40-0

CAS: 1273579-40-0 Cat. No.: C646731 Summenformel: C₂₄H₂₈N₄O₄ Molekulargewicht: 436.50 PubChem CID: 66577033

GRADE & PURITY ≥98%

Synonyms

ROCK-II inhibitor | (3S)-N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamide

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 ( IC 50 =1 pM) than ROCK1 ( IC 50 =52 pM). Chroman 1 also has inhibitory activity against MRCK , with an IC 50 of 150 nM

In Vitro

Chroman 1 (50 nM, 24 h) inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 0-12 h or 24 h Result: Reduced the number of apoptotic cells, reduced caspase-3/7 activation. Western Blot AnalysisCell Line: hESCs (human pluripotent stem cells) (WA09) Concentration: 50 nM Incubation Time: 24 h Result: Partially inhibited caspase-3 activation.

Form:Solid

IC50& Target:ROCK2|1 pM (IC|50|)|ROCK1|52 pM (IC|50|)|MRCK|150 nM (IC|50|)

Specifications

Synonyme

ROCK-II inhibitor | (3S)-N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromene-3-carboxamide

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 ( IC 50 =1 pM) than ROCK1 ( IC 50 =52 pM). Chroman 1 also has inhibitory activity against MRCK , with an IC 50 of 150 nM.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥98%

Namen und Kennungen

• Pubchem Sid: 528763914
• Isomere SMILES: CN(C)CCOC1=C(C=CC(=C1)C2=CNN=C2)NC(=O)[C@H]3CC4=C(C=CC(=C4)OC)OC3
• PubChem CID: 66577033
• Molekulargewicht: 436.50

Zugehörige Ziele (menschlich)

ROCK2 Tclin Rho-associated protein kinase 2 (6206 Activities)

Discover Target: ROCK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : ≥ 50 mg/mL (114.55 mM)
• Molekulargewicht: 436.500 g/mol
• XLogP3: 2.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• Exact Mass: 436.211 Da
• Monoisotopic Mass: 436.211 Da
• Topological Polar Surface Area: 88.700 Ų
• Heavy Atom Count: 32
• Formal Charge: 0
• Complexity: 607.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1