Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 7 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Cilastazol is a 2-oxo-quinoline with vasodilator, antimitogenic, antithrombotic, and cardiotonic properties. This compound has been shown to cause inhibition of adenosine uptake, eventually resulting in changes to cAMP levels. Studies have shown Cilostazol to be a potent inhibitor of PDE3A (phosphodiesterase 3A) in the cardiovascular system. In addition Cilastazol has also been observed to inhibit mitogenesis, migration of vascular smooth muscle cells, and platelet aggregation. Cilostazol displays a capacity to lower levels of serum triglycerides and cause some increase in HDL-cholesterol levels.
Phosphodiesterase III (PDE3) inhibitor, antimitogenic, antithrombotic, and cardiotonic agent.
| ALogP | 3.1 |
|---|
| Pubchem Sid | 504750599 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504750599 |
| Canonical Smiles | C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4 |
| IUPAC Name | 6-[4-(1-cyclohexyltetrazol-5-yl)butoxy]-3,4-dihydro-1H-quinolin-2-one |
| InChIKey | RRGUKTPIGVIEKM-UHFFFAOYSA-N |
| INCHI | 1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26) |
| Isomeric SMILES | C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4 |
| WGK Germany | 2 |
| RTECS | VC8277500 |
| Molecular Weight | 369.46 |
| Reaxy-Rn | 3632107 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3632107&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Quinolines and derivatives |
| Subclass | Quinolones and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Hydroquinolones |
| Alternative Parents | Hydroquinolines Alkyl aryl ethers Benzenoids Tetrazoles Heteroaromatic compounds Secondary carboxylic acid amides Lactams Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Tetrahydroquinolone - Tetrahydroquinoline - Alkyl aryl ether - Benzenoid - Azole - Heteroaromatic compound - Tetrazole - Carboxamide group - Lactam - Secondary carboxylic acid amide - Carboxylic acid derivative - Ether - Azacycle - Hydrocarbon derivative - Organic oxide - Organic nitrogen compound - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as hydroquinolones. These are compounds containing a hydrogenated quinoline bearing a ketone group. |
| External Descriptors | tetrazoles - lactam |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jan 26, 2026 | C129678 | |
| Certificate of Analysis | Oct 14, 2025 | C129678 | |
| Certificate of Analysis | Jul 09, 2024 | C129678 | |
| Certificate of Analysis | Jul 09, 2024 | C129678 |
| Solubility | DMSO 74 mg/mL Water <1 mg/mL Ethanol 6 mg/mL |
|---|---|
| Melt Point(°C) | 160 °C |
| Molecular Weight | 369.500 g/mol |
| XLogP3 | 3.100 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 7 |
| Exact Mass | 369.216 Da |
| Monoisotopic Mass | 369.216 Da |
| Topological Polar Surface Area | 81.900 Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 485.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Wen Huang, Yafei Li, Qianmin Fu, Ming Chen. (2021) Fabrication of a novel biochar decorated nano-flower-like MoS2 nanomaterial for the enhanced photodegradation activity of ciprofloxacin: Performance and mechanism. MATERIALS RESEARCH BULLETIN, [PMID:] [10.1016/j.materresbull.2021.111650] |
| 2. Xinyu Shan, Yichao Lu, Zhenyu Luo, Xiaoqi Zhao, Mei Pang, Hang Yin, Xuemeng Guo, Huanli Zhou, Junlei Zhang, Jiaxin Huang, Yingying Shi, Jinfang Lou, Lihua Luo, Jian You. (2024) A Long-Acting Lyotropic Liquid Crystalline Implant Promotes the Drainage of Macromolecules by Brain-Related Lymphatic System in Treating Aged Alzheimer’s Disease. ACS Nano, [PMID:38517764] [10.1021/acsnano.4c01206] |
| 3. Liu Tonglinxi, Liu Wen, Li Xinyue, Wang Hanyu, Lan Yushan, Zhang Shengmin, Wang Yujun, Liu Huiqing. (2024) Effect of environmental factors on adsorption of ciprofloxacin from wastewater by microwave alkali modified fly ash. Scientific Reports, 14 (1): (1-13). [PMID:39215074] [10.1038/s41598-024-70921-6] |
| 4. Runlin Han, Faxiang Feng, Zanming Zhu, Shi Su, Jingjing Wang, Chuxuan Shi, Guilin Dong, Hongbo Gu. (2025) Innovative bi-functional cellulose acetate/BiOCl photocatalytic membrane with excellent antibiotics degradation and photoresponsive antimicrobial performance. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, [PMID:] [10.1016/j.colsurfa.2025.138959] |
| 5. Longjie Xiao, Hongkui Zhang, Xue Song, Yongde Liu, Jie Zhang, Feiyue Wang, Guihua Yan, Han Zhang, Tianzeng Jin, Jihong Zhao. (2025) Competitive adsorption of oxytetracycline and ciprofloxacin on K2CO3-activated sycamore flocculent biochar. MATERIALS CHEMISTRY AND PHYSICS, [PMID:] [10.1016/j.matchemphys.2025.131899] |
| 6. Faxiang Feng, Zanming Zhu, Jiale Li, Shi Su, Guilin Dong, Guanhui Wang, Xiaobing Liu, Runlin Han. (2025) In-situ grown electrospun PI/BiOCl nanofiber membranes for efficient photocatalytic degradation of antibiotics. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, [PMID:] [10.1016/j.jphotochem.2025.117014] |
| 7. Silin Li, Wenjie Zheng, Wenlan Ji, Yunfei Shi, Tian Ren, Shihao Zhang, Xiao Wei, Yibin Wei. (2025) Engineering of catalytic Ce@SiC ceramic membranes with ozonation for efficient antibiotic degradation. DESALINATION, [PMID:] [10.1016/j.desal.2025.119815] |
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