CM-675 - 10mM in DMSO , CAS No.1872466-47-1

CAS: 1872466-47-1 Cat. No.: C655920 Molecular Weight: 536.62 PubChem CID: 136955224

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases -selective inhibitor, with IC 50 values of 114 nM and 673 nM for PDE5 and HDAC1 , respectively. CM-675 has potential to treat Alzheimer’s disease

In Vitro

CM-675 (29a) shows a significant time-dependent effect on class I HDAC inhibition, particularly towards HDAC2. For HDAC1, its inhibitory potency also increased significantly (~1 log unit) with the pre-incubation time: 673 nM (30 min), 180 nM (4 hours) and 69 nM (6 hours). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:HDAC1 673 nM (IC 50 , 30 min (time-dependent)) PDE5 114 nM nM (IC 50 )

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases -selective inhibitor, with IC 50 values of 114 nM and 673 nM for PDE5 and HDAC1 , respectively. CM-675 has potential to treat Alzheimer’s disease.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)CC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5N)OCC)C
• PubChem CID: 136955224
• Molecular Weight: 536.62