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COH34 - ≥99% , CAS No.906439-72-3
AVAILABLE TO ORDER
GRADE & PURITY ≥99%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC 50 of 0.37 nM. COH34 binds to the catalytic domain of PARG ( K d =0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors
In Vitro
COH34 efficiently kills PARP inhibitor-resistant cancer cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:IC50: 0.37 nM (PARG)
Specifications
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC 50 of 0.37 nM. COH34 binds to the catalytic domain of PARG ( K d =0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥99%
Names and Identifiers
| Canonical Smiles | CC1=CC=C(C=C1)SN=CC2=C(C=CC3=CC=CC=C32)O |
|---|---|
| IUPAC Name | 1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol |
| InChIKey | SFUAIBHPGDRCFL-XDHOZWIPSA-N |
| INCHI | 1S/C18H15NOS/c1-13-6-9-15(10-7-13)21-19-12-17-16-5-3-2-4-14(16)8-11-18(17)20/h2-12,20H,1H3/b19-12+ |
| PubChem CID | 135443632 |
| NSC Number | 191252 |
| Molecular Weight | 293.38 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
3D Structure
Interactive Chemical Structure Model
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 16.67 mg/mL (56.82 mM; Need ultrasonic) |
|---|
Solution Calculators
Reviews
Customer Reviews
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