Collagen IV（human）, CAS No.C390608

CAS: C390608 Cat. No.: C390608

GRADE & PURITY 0.5-5 mg/ml in 0.01mol/L PBS,＞95%

Übersicht

NCBI accession：NM_001845.4

UniProt accession：P02462

Binding Specificity: Laminin; Nidogen

Human collagen type IV is a native triple helix and heterotrimeric protein containing two α1-like and one α2-like genes. Type 4 collagen forms a sheet-like extracellular matrix in multicellular tissues that exists around certain cell types like adipocytes, skeletal muscle cells, heart muscle cells, and smooth muscle cells. Human Collagen IV is extracted from washed dissected tissue into dilute acetic acid after mild pepsin treatment. The Collagen type 4 was purified by using differential salt precipitation. Purity and retention of the native helical structure were controlled by SDS-PAGE and by reaction with anti-collagen type-specific monoclonal antibodies.

Physical form

Liquid purified protein.

Specifications

Product Name

Collagen IV（human）, CAS No.C390608

Spezifikationen & Reinheit

0.5-5 mg/ml in 0.01mol/L PBS,＞95%

Biochemische und physiologische Mechanismen

Human collagen type IV is associated with Alport and Goodpasture′s syndrome, as well as several rheumatological and dermatological diseases including, acquired epidermolysis bullosa.

Voraussichtliches Molekulargewicht

300 kDa

CAS

C390608

Molekültyp

Protein

Lagerung und Versand

Konzentration

0.5-5 mg/ml in 0.01mol/L PBS,＞95%

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Referenzen

1. Fanyan Chen, Bingkuan Zhu, Yu Fang, Zilüe Li, Zhigang Lei, Zechao Xue, Tao Shen, Sha Zhou, Xiaojun Chen, Lei Xu, Yalin Li, Jifeng Zhu, Wei Hu, Chuan Su.  (2025)  Schistosoma japonicum leishmanolysin SjLLPi1 facilitates the invasion of cercariae into the host skin.  PLoS Pathogens,  21  (8): (e1013446).  [PMID:40857348] [10.1371/journal.ppat.1013446]

Häufig gestellte Fragen

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is C390608.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.