Compound 48/80 trihydrochloride - ≥98% , CAS No.848035-21-2

CAS: 848035-21-2 Cat. No.: C649326 Summenformel: C₃₂H₄₈Cl₃N₃O₃ Molekulargewicht: 629.10 PubChem CID: 118797323

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Übersicht

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl- p -methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .

In Vitro

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC 50 values are 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter. ?\nCompound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 7-week-old Wistar male rats (fasted for 24 hours)Dosage: 0.75 mg/kg Administration: Intraperitoneal injection; Killed after 0.5, 3 or 6 h Result: Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter.

Form:Solid

Specifications

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl- p -methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48

Storage

Store at 2-8°C,Desiccated

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥98%

Namen und Kennungen

Kanonisches Lächeln

CNCCC1=CC(=C(C=C1)OC)CC2=CC(=CC(=C2OC)CC3=C(C=CC(=C3)CCNC)OC)CCNC.Cl.Cl.Cl

IUPAC Name

2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-N-methylethanamine;trihydrochloride

InChIKey

KIAWAQJORBNOIF-UHFFFAOYSA-N

INCHI

1S/C32H45N3O3.3ClH/c1-33-14-11-23-7-9-30(36-4)26(17-23)21-28-19-25(13-16-35-3)20-29(32(28)38-6)22-27-18-24(12-15-34-2)8-10-31(27)37-5;;;/h7-10,17-20,33-35H,11-16,21-22H2,1-6H3;3*1H

PubChem CID

118797323

Molekulargewicht

629.10

Chemische und physikalische Eigenschaften

• Löslichkeit: H2O : 25 mg/mL (39.74 mM; Need ultrasonic) DMSO : 10 mg/mL (15.90 mM; ultrasonic and warming and heat to 60°C)

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 848035-21-2, the molecular formula is C32H48Cl3N3O3, and the molecular weight is 629.10 g/mol. InChIKey KIAWAQJORBNOIF-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.