COTI-2 - 10mM in DMSO , CAS No.1039455-84-9

CAS: 1039455-84-9 Cat. No.: C420437 Summenformel: C₁₉H₂₂N₆S Molekulargewicht: 366.48

QUALITÄT & REINHEIT 10mM in DMSO

Synonyms

1-​Piperazinecarbothioi​c acid,4-​(2-​pyridinyl)​-​,2-​(6,​7-​dihydro-​8(5H)​-​quinolinylidene)​hydrazide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

COTI-2 COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.

Targets

p53 mutants

In vitro

The thiosemicarbazone COTI-2 is reported to promote refolding of mutant p53 and restore wild-type-p53 function. It is active against human tumour cell lines of various origins at nanomolar concentrations, induces cell death by apoptosis. COTI-2 is highly efficacious against multiple cancer cell lines from a broad range of human cancers both in vitro and in vivo. COTI-2 does not significantly inhibit over 200 kinases from major kinase pathways involved in cancer that were evaluated in both kinase assays and does not inhibit the ATPase activity of Hsp90, a ubiquitous molecular chaperone that plays an essential role in cell survival and cell cycle control.

In vivo

COTI-2 significantly inhibited tumor growth in the HT-29 human colorectal tumor xenografts at a dose of 10 mg/kg. COTI-2 also significantly inhibited tumor growth in the SHP-77 SCLC xenograft model at a dose as low as 3 mg/kg. Its treatment delays U87-MG, MDA-MB-231 and OVCAR-3 xenograft growth. COTI-2 treatment demonstrates a safe toxicity profile in vivo. COTI-2 selectively targets a wide variety of human cancer cell lines, as demonstrated by the in vitro data, while having little deleterious effects on normal cells.

Cell Research(from reference)

Cell lines：SHP-77 cells 

Concentrations：100, 250, 1000 nM 

Incubation Time：48 h 

Spezifikationen

Synonyme

1-​Piperazinecarbothioi​c acid,4-​(2-​pyridinyl)​-​,2-​(6,​7-​dihydro-​8(5H)​-​quinolinylidene)​hydrazide

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Produkteigenschaften

ALogP

3.825

hba_count

3

HBD-Zahl

1

Rotationsfähige Bindung

4

Namen und Kennungen

Pubchem Sid

528763794

Kanonisches Lächeln

C1CC2=C(C(=NNC(=S)N3CCN(CC3)C4=CC=CC=N4)C1)N=CC=C2

IUPAC Name

N-(6,7-dihydro-5H-quinolin-8-ylideneamino)-4-pyridin-2-ylpiperazine-1-carbothioamide

InChIKey

UTDAKQMBNSHJJB-UHFFFAOYSA-N

INCHI

1S/C19H22N6S/c26-19(23-22-16-7-3-5-15-6-4-10-21-18(15)16)25-13-11-24(12-14-25)17-8-1-2-9-20-17/h1-2,4,6,8-10H,3,5,7,11-14H2,(H,23,26)

Isomere SMILES

C1CC2=C(C(=NNC(=S)N3CCN(CC3)C4=CC=CC=N4)C1)N=CC=C2

Molekulargewicht

366.48

Reaxy-Rn

18407829

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18407829&ln=

Chemische und physikalische Eigenschaften

• DMSO (mg/ml) Maximale Löslichkeit: 73
• DMSO (mM) Maximale Löslichkeit: 199.1923161
• Wasser (mg/ml) Maximale Löslichkeit: ＜1