Crocetin disodium - ≥95% , CAS No.591230-99-8

CAS: 591230-99-8 Cat. No.: C651815 Summenformel: C₂₀H₂₂Na₂O₄ Molekulargewicht: 372.37 PubChem CID: 10287099

GRADE & PURITY ≥95%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Übersicht

Crocetin (Transcrocetin) disodium, extracted from saffron ( Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity.

In Vitro

Crocetin (Transcrocetin, trans-Crocetin) disodium, a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity and is thought to be responsible for the CNS activity of saffron.To ensure unchanged viability of Caco-2 cells throughout the transport experiments, cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) and crocin-1 (250-1000 µM) reveal no negative significant changes in cellular viability. Crocetin disodium at 10 µM level does not change viability while higher concentrations (40-160 µM) reduces significantly cellular viability. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:NMDA Receptor

Specifications

Spezifikationen & Reinheit

≥95%

Biochemische und physiologische Mechanismen

Crocetin (Transcrocetin) disodium, extracted from saffron ( Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity.

Storage

Store at 2-8°C,Desiccated

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

ANTAGONIST

Reinheit

≥95%

Namen und Kennungen

• Isomere SMILES: C/C(=C\C=C\C=C(\C=C\C=C(\C(=O)[O-])/C)/C)/C=C/C=C(/C(=O)[O-])\C.[Na+].[Na+]
• PubChem CID: 10287099
• Molekulargewicht: 372.37

Chemische und physikalische Eigenschaften

• Löslichkeit: H2O : 16.67 mg/mL (44.77 mM; Need ultrasonic) DMSO : 1 mg/mL (2.69 mM; ultrasonic and warming and heat to 80°C)
• Molekulargewicht: 372.400 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 372.131 Da
• Monoisotopic Mass: 372.131 Da
• Topological Polar Surface Area: 80.300 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 597.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 7
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 7
• Covalently-Bonded Unit Count: 3

XLogP3