CTX-471 , CAS No.2377152-49-1

CAS: 2377152-49-1 Cat. No.: C651743 Summenformel: CT

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

CTX-471 is a fully human monoclonal antibody of CD137 . CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K d values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer

In Vitro

CTX-471 (5-500 nM) has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K d values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 binds to a unique epitope on CD137. CTX-471 (0.1-100 nM; 1, 10 μg/mL; 3 days) increases IFN-y production by human T cells in an Fcy receptor-dependent (FcyR-dependent) manner in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CTX-471 (i.p.; 150 μg) exhibits curative monotherapy activity in various syngeneic tumor models and shows a unique ability to cure mice of very large tumors.\nCTX-471 (i.v.; 10-80 mg/kg; on days 0, 7, 14, and 21) is well tolerated, with no signs of hepatic toxicity in high doses. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: BALB/c mice Dosage: 150 μg; 10-80 mg/kg Administration: i.p., on days 6, 9, 12, 19 and 26( or on days 7, 10, 13, 20, and 27 or on days 0, 3, 6, and 9); i.v., on days 0, 7, 14, and 21 Result: Required T and NK cells, as well as FcγR engagement to achieve its efficacy. Do not induce hepatic inflammation.

Form:Liquid

IC50& Target:Kd for CD137: 50 nM (human),61 nM (cynomolgus macaque),748 nM (mouse)

Specifications

Biochemische und physiologische Mechanismen

CTX-471 is a fully human monoclonal antibody of CD137 . CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K d values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodul

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

• Kanonisches Lächeln: [3H][C][X471]