10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 9 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.
In vitro
Curcumol induced cell death in human lung adenocarcinoma (ASTC-a-1) cells by inducing G(2)/M phase arrest, nuclear fragmentation, phosphatidylserine externalization and a rapid translocation of Bax from cytosol into mitochondria. While, caspases are not involved in Curcumol-induced apoptosis. Curcumol also benefits rheumatoid arthritis treatment through suppressing the fibroblast-like synoviocytes (FLS) proliferation and DNA synthesis. It attenuates PDGF-BB-induced Jak2 phosphorylation and downregulates STAT1 and STAT3 DNA-binding activities.
In vivo
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:
| Isomeric SMILES | C[C@H]1CC[C@@H]2[C@]13C[C@H]([C@](O3)(CC2=C)O)C(C)C |
|---|---|
| Molecular Weight | 236.35 |
| Reaxy-Rn | 2111893 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2111893&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubility | Solubility (25°C) In vitro DMSO: 45 mg/mL (200.7 mM); Water: 45 mg/mL (200.7 mM); Ethanol: 20 mg/mL (89.2 mM); |
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| 1. Xuelin Duan, Tiejian Zhao, Jiaru Wang, Jiahui Wang, Yang Zheng. (2023) Curcumol targets glutaminase 1 to regulate glutamine metabolism and induce senescence of hepatic stellate cells. European Journal of Integrative Medicine, [PMID:] [10.1016/j.eujim.2023.102278] |
| 2. Yang Zheng, Tiejian Zhao, Jiaru Wang, Ruizhu Jiang, Jinbiao Huang, Weimin Li, Jiahui Wang. (2022) Curcumol alleviates liver fibrosis through inducing autophagy and ferroptosis in hepatic stellate cells. FASEB JOURNAL, 36 (12): (e22665). [PMID:36398583] [10.1096/fj.202200933RR] |
| 3. Yang Zheng, Jiahui Wang, Jiaru Wang, Ruizhu Jiang, Tiejian Zhao. (2022) Gut microbiota combined with metabolomics reveal the mechanism of curcumol on liver fibrosis in mice. BIOMEDICINE & PHARMACOTHERAPY, [PMID:35653891] [10.1016/j.biopha.2022.113204] |
| 4. Yang Zheng, Jiaru Wang, Tiejian Zhao, Lei Wang, Jiahui Wang. (2021) Modulation of the VEGF/AKT/eNOS signaling pathway to regulate liver angiogenesis to explore the anti-hepatic fibrosis mechanism of curcumol. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:34358654] [10.1016/j.jep.2021.114480] |
| 5. Yang Zheng, Jiahui Wang, Jiaru Wang, Haiyuan Xie, Tiejian Zhao. (2020) Effect of Curcumol on the Fenestrae of Liver Sinusoidal Endothelial Cells Based on NF-κB Signaling Pathway. Evidence-based Complementary and Alternative Medicine, [PMID:32595742] [10.1155/2020/8590638] |
| 6. Kong L.M., Xu S.Y., Hu H.H., Zhou H., Jiang H.D., Yu L.S., Zeng S.. (2014) Identification of CYP2C19 inhibitors from phytochemicals using the recombinant human enzyme model. PHARMAZIE, 69 (5): (362-366). [PMID:] [10.1691/ph.2014.3194] |
| 7. Shuai-Nan Zhang, Qi Liu, Xu-Zhao Li, Wu-De Yang, Ying Zhou. (2023) Liver protein and metabolite biolabels reveal hepatoprotective effects and active compounds of Eucommiae folium: Exploration of new application of herb based on multi-omics and bioinformatics. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, [PMID:38008044] [10.1016/j.jpba.2023.115870] |
| 8. Jingjing Yang, Hai Zhu, Wenhao Liang, Xingzeng Zhao, Min Yin, Xu Feng, Bi Wang. (2024) Fungicidal activity of curcumol against Phytophthora capsici via inhibiting phosphatidylcholine biosynthesis and its systemic translocation in plants. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, [PMID:39672648] [10.1016/j.pestbp.2024.106214] |
| 9. Yao Wang, Junhua Qiu, Chengwei Wang, Ruiyu Yang, Fuyou Guo, Tian Li, Shili Li, Lei Yang, Wei Ding. (2026) Sustainable Strategy of Natural trans-Anethole in Controlling Bacterial Wilt: Virulence Suppression and Beneficial Microbiome Enrichment. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:41568748] [10.1021/acs.jafc.5c13627] |
