Cyclovirobuxine D - Moligand™, 10 mM in Ethanol , CAS No.860-79-7

CAS: 860-79-7 Cat. No.: C1499752 Summenformel: C₂₆H₄₆N₂O Molekulargewicht: 402.364 EG-Nummer: 632-924-0

GRADE & PURITY Moligand™, 10 mM in Ethanol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla . Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR. Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis. Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction.

Specifications

Spezifikationen & Reinheit

Moligand™, 10 mM in Ethanol

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Namen und Kennungen

• Isomere SMILES: C[C@@H]([C@H]1[C@@H](C[C@@]2([C@@]1(CC[C@]34[C@H]2CC[C@@H]5[C@]3(C4)CC[C@@H](C5(C)C)NC)C)C)O)NC
• Molekulargewicht: 402.364
• Reaxy-Rn: 47748950
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=47748950&ln=

Chemische und physikalische Eigenschaften

• Brechungsindex: 1.55
• Siedepunkt (°C): 495.7 °C
• Schmelzpunkt (°C): 219-222°C

Referenzen

1. Ting Xue, Yaodong Chen, Jia Xu, Weiqin Du, Pengzhou Kong, Xinri Zhang.  (2023)  Cyclovirobuxine D inhibits growth and progression of non‑small cell lung cancer cells by suppressing the KIF11‑CDC25C‑CDK1‑CyclinB1 G2/M phase transition regulatory network and the NFκB/JNK signaling pathway.  INTERNATIONAL JOURNAL OF ONCOLOGY,  62  (5): (1-21).  [PMID:36929198] [10.3892/ijo.2023.5505]

2. Fengqi Jiang, Yaodong Chen, Shuo Ren, Zizhuo Li, Kan  Sun, Yanwei Xing, Yuekun Zhu, Daxun Piao.  (2020)  Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.  INTERNATIONAL JOURNAL OF ONCOLOGY,  57  (1): (183-196).  [PMID:32319595] [10.3892/ijo.2020.5038]

3. Jiuwei Zhang, Yaodong Chen, Jing Lin, Ruimei Jia, Tingting An, Tianxiu Dong, Yu Zhang, Xiuhua Yang.  (2020)  Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma.  DNA AND CELL BIOLOGY,  39  (3): (355-367).  [PMID:31913706] [10.1089/dna.2019.4990]

4. Jiang Xinru, Li Hongdan, Liu Yang.  (2024)  Cyclovirobuxine D inhibits hepatocellular carcinoma growth by inducing ferroptosis of hepatocellular carcinoma cells.  Discover Oncology,  15  (1): (1-11).  [PMID:38563866] [10.1007/s12672-024-00940-2]

5. Jinku Guo, Yingfeng Cao, Kaipen Jin, Bing Liu, Wei Wang, Chen Chen, Jun Xie, Ankai Xu.  (2026)  Cyclovirobuxine D suppresses cancer stemness in osteosarcoma with implication of the noncanonical NF-kappaB pathway.  Frontiers in Pharmacology,      [PMID:41868117] [10.3389/fphar.2026.1746984]

Häufig gestellte Fragen

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 860-79-7, the molecular formula is C26H46N2O, and the molecular weight is 402.364 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.