Daphnetin - 10mM in DMSO , CAS No.486-35-1

CAS: 486-35-1 Cat. No.: D408432 Summenformel: C₉H₆O₄ Molekulargewicht: 178.14 Beilstein Registry Number: 18(5)3,211 EG-Nummer: 207-632-8

QUALITÄT & REINHEIT 10mM in DMSO

Synonyms

7,​8-​dihydroxy-2H-​1-​benzopyran-​2-​one

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibitsEGFR,PKAand PKC withIC50of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.
In vitro

Daphnetin strongly inhibits not only EGF receptor-catalyzed tyrosine phosphorylation of exogenous substrate but also PKA and PKC activities. Daphnetin inhibits MCF-7 estrogen-responsive human carcinoma cell line at 24-hour exposure with IC50 of 73 μM. Daphnetin reduces the level of cyclin D1 even at 50 μM. Daphnetin protects the cortical neurons against dexamethasone-induced reduction of cell viability in a dose-dependent manner. Daphnetin inhibits the activities of endogenous or recombinant TaPRK in a specific and dose-dependent manner. daphnetin causes a 50% inhibition (IC50) of 3H-hypoxanthine incorporation by Plasmodium falciparum at concentrations between 25 μM and 40 μM. Daphnetin inhibits the mitogenic signalling of ERK1/ERK2.

In vivo

Daphnetin at 140 mg/kg significantly decreases uterine weights by 39.5%. Two and 8 mg/kg administration of Daphnetin could improve the performance of stress mice in Morris water maze tests and forced swimming tests. Daphnetin significantly prolongs survival of P. yoelli-infected mice.
Cell Data

cell lines：

Concentrations：12.5 μM, 25 μM, 50 μM, 100 μM, 200 μM

Incubation Time：24 hours, 48 hours, and 72 hours

Powder Purity:≥99%

Spezifikationen

Synonyme

7,​8-​dihydroxy-2H-​1-​benzopyran-​2-​one

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

Isomere SMILES

C1=CC(=C(C2=C1C=CC(=O)O2)O)O

RTECS

GN6382600

Molekulargewicht

178.14

Beilstein

18(5)3,211

Reaxy-Rn

9372

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9372&ln=

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 52 mg/mL (201.37 mM); Ethanol: 52 mg/mL (201.37 mM); Water: Insoluble
• Schmelzpunkt (°C): 256°C

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 486-35-1, the molecular formula is C9H6O4, and the molecular weight is 178.14 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.