DBPR108 - 10mM in DMSO , Dipeptidyl peptidase IV inhibitor, CAS No.1186426-66-3, Dipeptidyl peptidase IV inhibitor

CAS: 1186426-66-3 Cat. No.: D656743 Molecular Weight: 324.39 PubChem CID: 44201003

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9.IC50 value: 15 nM Target: DPP4 inhibitorDBPR108 is an IC50=15 nM DPP IV inhibitor displays a more than 3000-fold selectivity over DPP8 DPP9, FAP and DPP-II. TThe in vivo effects of DBPR108, including inhibition of plasma DPP-IV activity and suppression of blood glucose elevation, were also demonstrated. DBPR108 is a potent, selective, long-acting and safe DPP-IV inhibitor as a potential treatment of type 2 diabetesmellitus.

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9.\nIC50 value: 15 nM \nTarget: DPP4 inhibitor\nDBPR108 is an IC50=15 nM DPP IV inhibitor displays a more than

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Dipeptidyl peptidase IV inhibitor

Product Properties

• ALogP: 0.2

Names and Identifiers

• Isomeric SMILES: CC(C)(CC(=O)N1CCCC1)NCC(=O)N2C[C@H](C[C@H]2C#N)F
• Alternate CAS: 1186426-66-3
• PubChem CID: 44201003
• MeSH Entry Terms: (2S,4S)-4-fluoro-1-(2-((2-methyl-4-oxo-4-pyrrolidin-1-ylbutan-2-yl)amino)acetyl)pyrrolidine-2-carbonitrile;DBPR108
• Molecular Weight: 324.39

Associated Targets(Human)

DPP4 Tclin Dipeptidyl peptidase 4 (3 Activities)

Discover Target: DPP4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)